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by: Vanessa Beck

GeneRegulation.pdf Biology 107

Vanessa Beck
GPA 2.8
Cell Biology and Genetics
William Davis

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About this Document

Gene Regulation
Cell Biology and Genetics
William Davis
Class Notes
25 ?




Popular in Cell Biology and Genetics

Popular in Biology

This 1 page Class Notes was uploaded by Vanessa Beck on Tuesday February 17, 2015. The Class Notes belongs to Biology 107 at Washington State University taught by William Davis in Spring2015. Since its upload, it has received 162 views. For similar materials see Cell Biology and Genetics in Biology at Washington State University.


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Date Created: 02/17/15
February 11 2015 1 Gene Regulation a Importance i Prokaryotes 1 Energy conservation 2 Allow them to respond to their environment 3 mRNA and transcription at once a use of operons is a key strategy b Operon i Cluster of functionally related genes and their control sequences 1 Transcribed as a unit ii DNA Sequence 1 Promoter 2 Operator c Lac Operon Negative Regulation i E Coli can use lactose for energy prefers glucose 1 Lactose glucose galactose 2 E coli make proteins for bringing in and metabolizing lactose ii When lactose is absent 1 Repressor binds to the operator a Blocks RNA polymerase b Prevents transcription of lactose metabolism genes 2 Regulatory gene a LacI iii When Lactose is present 1 Inducer binds to repressor a Repressor comes off of operator b RNA polymerase is no longer blocked 2 Transcription occurs d Lac Operon Positive Regulation i E coli prefers glucose to lactose 1 Glucose is used up before lactose ii Ability to sense glucoses 1 Cyclic AMP cAMP to detect glucose a cAMP is high I Activates CAP 2 CAP I catabolite activator protein a CAP stimulates transcription iii The cell can use lactose


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