chap5 notes BME3403 EABS
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Date Created: 02/21/15
About this Chapter Cell membrane structures and functions Membranes form fluid body compartments r 5 Membranes as barriers and gatekeepers How products move across membranes Distribution of water and solutes in cells amp the body 0 Chemical and electrical imbalances 39 Membrane permeability and changes Membrane Dynamics W lain2390 Co i flthaL a Pho lohgl 9ici billaauzrs V S39lml 3 mm quot791 Ethanol 0 mike Cl d P W39Ql ete l kj39ral C whbmu I 5 WM 3 WC lvlt CCU b 0 39f 3 FIFErt 3 I thyme S llPi cl gquot Membranes two meanings Cell Membranes Overview Membranous tissues Example pericardial membrane Cell structure amp support Barrier isolates cell impermeable Chemically Physically I 39 317 Sig W Regulates exchange semipermeable v g i 39 113 1 mummy Epithelial tissues one to many cells thick Cell Membranes plasmalemma enclose cells a 1lls Cell communication ummg quotat rigswas WWWW Epi i39lxtwml MoistU quot WV Dos beauth EP39JINUQI ALO MCquothhlt llMY i Limle 031 magigt4 95f IOLUVLQ n jva39 109p Exhawlular I botanic T atlme on hccppcv l rm mom lbs m 39 lere 39 ICASColof g a m mmgmid 379 v F 94 Space Cell Membranes Overview Membrane Structure 11maalnxcuo 39 C E m quot 3 x 2 l U Ar Phospholipid bilayer and cholesterol Membrane proteins MW k 7 Peripheral associated 39 tiilmlmiquot lntegl al N61 Ohm O lexcllx W DFW g V l0 mlmcwww quot WHY 3mm nd SVC C Q 4 XXN39MCULULCAV 301QQ 3 race u WASCulQ r 59ng a oillcgrui x cm 9 Was I 0H0 quot SYN luMl Milliquotle hmmm nll gguul anhluiuyvjug39im Mi ililuini figannmg Mcvmggunr mmmmu mm cellular Cl Structure xht UL uvm39r 39 Cell polarity L QW CU fW QdK Phosphorylation Extracellular matrix n 1 ngI k l39l n Malinde munt u an a m xlmwiuiar it Unfth I S b 0 9 cl 1 ch SCCl f 0 wast lcniccjw 61 Millh 615 Hrg arich asia Set I LLOSV T i am On pmrcfnS Structural Membrane Proteins MembraneSpanning Membrane Proteins that Bind Molecules Extracellular IIud Carbohydrate External reactions Ligand binds to Ligandreceptor complex r a cell mambmnl triggers in aoellular response I r l I Internal reactions Wm N v r I39 l l a r V a G 5quot U i quotl 3 i c i 39 l Intracellular uid L Phosphate U M y xgmc 2E1 I Exa m ple 39 Ho rm 0 nes nmmmwm d cam 39 Vow l Cell recognition This membranespanning protein crosses the membrane seven times m 0 I ecu l es 39 x a Cl Figure 56 Cell mcmbmnc receptor Figure 5 5 Mcmbram spaiming proteins H l m r l mmml39l r 39irrnzn a V a pressva 5301 Transporter Proteins Transporter Proteins Move Products Through Membrane Move Products Through Membrane m form an open channel ides oi the membrane Op n bf Clo Sta quot ECF m GatEd W 3Uquot 31 0 15 4 WC Cequot 739 i r 39 r membrane 1 i39 Ki g 39 ll m cccccc 4 m quot39 to SUbStrate Carrier open Same carrier to CF open to ECF Slower transport p a Lonborn uh o n all quot CW lam I i 39 17 5quotquot 571 TmSPO pmleinsofmcocll mth g a vx l S U m L rupiwiSAM mden 1m MHMN WWWY w I n w 8 LuWt cal l l39 U l SOiHnauJil39 it0amp6 Transporter proteins Membrane Carbohydrates Move Products Th rough M embra he Form EXtemal G IVCOCa IVX The term was initially applied to the Qolysafnharide matrix have gates re usuau closed excreted by epithelial cells forming a coating on the surface of n n no most of c to chemical epithelial tissue their time in the open slate mechanical Of electrical signals Include I and m ECF an m quot Cell membrane fdp39 marten w any In sun m1 l V 1 Irtw39u 1 39 mum cfmd n til39nhm Cd Imw um martTut nut drawnm quot4an Hpquot 3quot lulu ul39ancl quotMau iunr s II No l id nmlu r vane moiii when 0 C so 0 3amp8 e5 95 x Y f w The Glycocalyx meohydmlcrich peripheral ton of the mmvnnl urfacr coating in the momme in most eukaryotlc 5115 Description The outer surface of cells is covered with lipopolysacdmride hairs consisting of 9 coproteins and glycolipids which are called glycocalvx39 omens of the glycocalyx include both compounds covalently bound t 0 to 1 leaner mom 39 39 n the cell audace and additicmal Wotmm are noncovalently attached to them some of m adsorbt components of kah makes it dif cult such matrices and cell membrane Glycocalyx is as a protective law an 1h msrl wall against pathogenic effects a network barrier to the movement of molecules It is assumed that the mdothelial glycocalyx has a definite ultrawucture and may be connected wnh the cytoslccleton to serve as a mechanochcmical vansduccr of blood flow effects Shear stress into other processes of cell signalmg MrsRLQ ulULu Ml 39lx LeviLA 0397 o ob 9w gamma as QWi le WW Wm we Figure 1 Role of the Endothelial Glycocalyx Layer in the Use of y Functions of the Glycocalyx The slrucluro and function of the endothelial glycooalyx layer a web of membranebound glycoproteins and proieoglycans on ondolhalial cells are key determinants of membrane i permeability n various vascular organ Protection Cushions the glasma membrane and protects it from chemical injury systems Panel A shows a heallhy endorhelial glycocalyx layer and Immunity to infection Enables the Immune system to recognize and selectively attack Panel B shows a damaged endothelial glycocalyx layer and fore gn or amsms resultant eflect on ermeahiiii ncludmg me mlme of y Defense against cancer Changes in the glycocalyx of gar1 er9L cells enable the 39quot 5 immune s stem to recognize and destroy them conditions em Transplant compatibility Forms the basis for compatibility of blood transfusions tissue ELM and organ transplants i 39 Cell adhesion Binds cells together so that tissues do not fall apart inflammation regulation Glycocalyx coating on endothelial walls in blood vessels i prevents leukoc es from rollingbinding in healthy statesli1 1 Fertilization Enables Mto recognize and bind to eggs 39 Embryonic development Guides embgonic cells to their destinations in the body ansg lanh Can pohbalibj pm dn39en M U QCJMlO I gvl m39orx o in amnnuhe I inl LCJL hLOn Membrane Proteins and Functions Reviewed Body FIUId Compartments CJCrlL w I 39 new arr can be categorized according to 7 s 7quot e v 39 39 9 Selene Funcllon 39 L L man I Peripheral i HA semisd g m M am i are arrrivalquot Tam 5 morons i prolensJi areacfwein quoti i v39 quot Ceiliunciions letosJielelon Receptor l I cIla 91 gm 1 l l 1 mediaed l 39 ooooo i Interstitial u ii 1 1 l inxvismul rm 7 so his fie We 1 Openchannels iGaltd climmdsi illlelacoilsmi m I Aw 4 A V quot E T i I i fiv open micuse Mechanicaw v I Chemically 9mm Vailagcqaled Md 1 iwwit r mij channel canquot I channel O 1quot Figure 543 Body fluid cumpzmmcnls i39npuxgnl v s i J 5mm Ann SIZ Map of membrane pmlcins quot igl J L39 no wmi an yiii my n ivnvmm 39Lniiiig n lacyroil WV l nl murmur 3 whim slimonincrummy en zxkjrrws Ecopier S i ij am Whomrm let ms Transitwars i SimMai Slingm clifwsiori Moire scvWHM 15 Aviva quot392 quot WWW Lonthbai grade lea 5L4qu Passive mod to W 3 WQWSPOHL Diffusion Passive amp down a concentration gradient Energy requirements Stops at equilibrium 0 Physical requirements Rate factors membrane temperature distance amp size Overview of Movement Across Membranes Fldl39l Law of Damion 521 Figure 5H Map of the ways molecules move across cell membranes Figure 516 Fick s 13 0139di 39u5iun twin 171 Low bimsicw Pakil framwi f m A337 WW9 Mt w mum M Aon llwW m9 Eurom may enqu V 0M 9 m was Carrier Mediated Transport Facilitated Diffusion Can be Passive or Active Uses transport proteins Passive Diffusion to Equilibrium Guccso SIm r Uniport 39 Cotransport Symport Antiport gure 517 1 va orwnicr ulediulcd lmnspon Facilnlmed diffusion r I qr dawns u39t Barnum slaps J not 2 u l nahEquot l c 121 39r Wiccam1 Cir w39l39i39ral f x qvauie39w cincrz39i ral n r isszle 39wd ClSVS iCL EY39E cell is 530 icr left 66 V r s I r 8 X0 szD39n l 1 39l39b39 39 M A L gt a r K l ligurc l 1 usmnsopsn cqun num panoramlc 0 u m mm in pan um in39urr Vunlnlrw39l 39 39 39 quotTruyf xquot w I mvmzhgmma moms lx39 licl 7m39l Iu1 l39t mesis quot Vim U hSiS d w USWD 9i 3 v WW o mm Mule gt t v QCr in own 53 swmmmv 0
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