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BIOL 3000 Lecture 30 notes

by: Kennedy Finister

BIOL 3000 Lecture 30 notes BIOL3000

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Kennedy Finister
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Rita Graze
Class Notes
Genetics, auburn, Auburn University, Biology, biol3000, Science, Biomedical Scienses
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This 1 page Class Notes was uploaded by Kennedy Finister on Saturday April 23, 2016. The Class Notes belongs to BIOL3000 at Auburn University taught by Rita Graze in Fall 2015. Since its upload, it has received 21 views.


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Date Created: 04/23/16
Genetics Lecture 30 April 22, 2016 1. Mutations A. What is a Mutation? a. Mutation- • an inherited change in the specific genetic information. The mutation can be inherited cell to cell or generation to generation. b. We have learned that structure or configuration of a peptide chain confers its function. c. Therefore, if you alter structure you may possibly alter function d. If you change the sequence of the DNA then you could possibly change the expressed phenotype e. Generates all genetic variation, including disease. B. Where do Mutations happen? a. Somatic mutations occur in non reproductive cells, and are passed to new cells through mitosis creating a clone of cells having the mutant gene b. Germ line mutations occur in cells that give rise to gametes. c. Meiosis and sexual reproduction allows germ-line mutations to be passed to approximately half of the next generation who will carry the mutation in all their cells. d. Somatic Cells (non sex cells) • any mutations that occur here during the lifetime of the organism, depending on the stage of development, can have differential effects on phenotype ranging from silent to severe. However, any effect is only felt by that organism and the mutation is not passed on to the next generation. e. Germ Cells (sex cells/ gametes) • Mutations that occur on the DNA which is carried in the sperm or the ova can be passed on to the offspring. C. Coding Mutation a. Sickle Cell Disease: in unaffected individuals, RBC’s flow through the circulatory system unaffected b. Affected individuals have blood cells with a “sickle” shaped phenotype that causes blockage of blood flow. c. Hemoglobin: Heme groups contain iron that binds to oxygen and transports it from the lungs to other tissues of your body. d. Hemoglobin Beta: Sickle Cell is caused by a point mutation in the 6 codon. e. The point mutation results in the change from one AA to another, A missense mutation. f. Change from glutamic acid to valine changes in the quaternary structure.


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