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chapter 6

by: Kathleen Quijada
Kathleen Quijada
GPA 3.46
Engineering analysis of biological systems EABS

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Hello! Chapter 6 for this week of notes! Enjoy!
Engineering analysis of biological systems EABS
Class Notes
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This 9 page Class Notes was uploaded by Kathleen Quijada on Friday February 27, 2015. The Class Notes belongs to BME3403 EABS at Florida International University taught by Dr.Brown in Fall2015. Since its upload, it has received 79 views. For similar materials see Engineering analysis of biological systems EABS in Biomedical Sciences at Florida International University.

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Date Created: 02/27/15
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electrical Signals A 39 jiL39T FLi39sz39 39F il i VE U P W Electrical signal down axon Signal molecule neurotransmitter to target cell Hormone transported via blood to target Sfl ICLPH c 39 Mmlvavxgmi llef CutC Chri Hulajeel Figure 6 2b a Long distance ccllloccll communication L m m m1quotfigggjgn gz klnkgng distance cellloccll communication NJCLm lWrmoM VS humoM l l 1r lztx wwwcxrzmi Eixnlirr in withhm 1 nmmw39innv 7 4 12 395 L C mamae I quot39 CQWM P39 mmm KM at ha 5 3 bait 216 y r n H CMALUC lm a 393 fpfd SDLJOLQ w nuC fQu ffC jafbgw Signal Pathways Receptor locations Signal mmecurel Cytosollc or Nuclear mndsfo l gt Lipophilic ligand ece or enters CEquot Signal molecule ligand Rproltgin Receptor n Um vmzmb YCWLQ I Li I cylosal In nuceus molacu as i use through the cell membrane and Often activates gene Slower response biquott quot s quot 39 39 nuc ear receptors Intracellular signal VJWS L l39 g 39 Ce membrane I I 39 39 quot 39 39 39 I 1 U V r Target pretem L39POPh bC gand Wm rquot 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molecules targeted to a cell bind at the cell surface to receptors embedded in the plasma membrane The signal is usually passed om a 7helix receptor to an Only signal molecules able to cross intracellular G protein the plasma membrane e g steroid hormones interact with intracellular receptors 39 Sevenhelix receptors are thus called GPCR or G ProteinCoupled Receptors 0 Approx 800 different GPCRs are encoded in the human genome A large family of cell surface receptors have a common structural motif 7 transmembrane ahelices iL the rst of these to have its 7 helix structure con rmed by Xray crystallography Rhodopsin PDB was 04 Q 030me leucotc on L it ioQ Q J t o as Stimulatorv and Inhibitory G Proteins 0 G proteins are heterotrimeric with 3 subunits 05 6 7 Effects liomwne 39 Rs 7 Hormone Bi 9 A G protein that activates cyclic AMPformation within a cell is called a stimulatory Gprotein designated Gs mquot39 quotquot39quot quot quot quot P quotquot quot Inhibitory wguimivc 0 Protein Gi 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