Organic reactions week 3
Organic reactions week 3 CHEM 1200
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This 1 page Class Notes was uploaded by Alexi Martin on Monday May 9, 2016. The Class Notes belongs to CHEM 1200 at Rensselaer Polytechnic Institute taught by Dr. Alexander Ma in Spring 2016. Since its upload, it has received 31 views. For similar materials see Chemistry II in Chemistry at Rensselaer Polytechnic Institute.
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Date Created: 05/09/16
Crown Ethers solvated cation, so nucleophilic strength of anion increases F becomes good nucleophile with this:extracts other halide SN2 SN1 CH3X>1>2 3>2 Strong nucleophile Weak nucleophilic solvent Polar aprotic solvent Polar protic solvent rate=k[alkyl halide][Nuc:] rate=k[alkyl halide] Inversion chiral C racemization No rearrangements Rearranged products Substitution vs. elimination SN2 favor E2 SN1 favor E1 Sn1 contained with E1 vice versa Presence of heat elimination, absence substitution, increase in temperature increase in the likelihood of elimination increases entropy Strength of nucleophile determines order: strong nucleophiles or bases bimolecular reaction Primary halides undergo SN2 (less steric hindrance methyl halides) Tertiary halides mixture or SN1, E1 or E1 (no SN2) Bulky bases undergo elimination See powerpoint for examples *know clicker problems *
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