MCDB 1150 Week 2 Typed Notes
MCDB 1150 Week 2 Typed Notes MCDB 1150
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This 2 page Class Notes was uploaded by Kristen Williams on Thursday September 1, 2016. The Class Notes belongs to MCDB 1150 at University of Colorado at Boulder taught by Jennifer Martin, Nancy Guild in Fall 2016. Since its upload, it has received 4 views. For similar materials see Introduction to Cellular and Molecular Biology in Biology at University of Colorado at Boulder.
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Date Created: 09/01/16
Molecular function follows molecular structure The structure of a molecule determines its function! • Macromolecules Proteins Lipids Carbohydrates Nucleic Acids • Complementary surfaces Enzymes/substrates Receptors/Ligands Antibodies/antigens Lock and Key mechanism • Carbon, Nitrogen, Oxygen Found abundantly in nature Outer shell of electrons is not full • How molecules interact in cells Atoms-> small molecules -> polymers -> macromolecular complexes • Life is based on interactions between molecules • Diﬀerence between an atom and a molecule Molecules are groups of atoms • Kinds of chemical interactions Covalent bonds (electron sharing) ‣ Polar covalent • Electrons not shared evenly (H2O) • Hydrophilic • Water soluble • Chemically reactive • Contain one or more electronegative atom Flourine is the most electronegative Oxygen is the second most Determine electronegativity ‣ More protons in the nucleus the more electronegative ‣ Size of the atom- distance the bonding electrons are from the nucleus • The bigger the atom the less electronegative it is • Size is inversely correlated • # of protons is positively correlated ‣ Nonpolar covalent • Electrons shared evenly (H2) • Between atoms with very similar negativity • Hydrophobic • Insoluble in water • Not chemically reactive • Bonds Single: Water, ammonia, methane Double: Carbon • Atoms of a polypeptide linked by covalent bonds • Atoms of nucleic acids (DNA, RNA) linked by covalent bonds Noncovalent covalent (elecrostatic) ‣ Weak attractive forces between positively and negatively charged regions within a molecule between two nearby molecules ‣ NOT stable ‣ Hydrogen bonds • Form between molecules w/ POLARIZED covalent bonds ‣ Ionic bonds ‣ Hydrophobic/hydrophilic ‣ Van der waals forces
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