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Intro to BioInformatics

by: Alabian Landrum

Intro to BioInformatics BINF 1101 - 001

Alabian Landrum
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The first 2 days of notes
Introduction to Bioinformatics and Genomics
Lawrence Edward Mays
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This 3 page Class Notes was uploaded by Alabian Landrum on Saturday September 3, 2016. The Class Notes belongs to BINF 1101 - 001 at University of North Carolina - Charlotte taught by Lawrence Edward Mays in Fall 2016. Since its upload, it has received 3 views.


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Date Created: 09/03/16
 Genome o Entire genetic makeup  Chromosomes o 23 pair atics  o Sex chromosomes o 16p13.12 16 refers to the 16th chromosome p for petit q  because it's after p  Genes  o Pieces of the genome that codes for a protein/proteins  o Produces RNAs   Base Pair  o Thymine o Cytosine o Adenine o Guanine  Aristotle (382­322 B.C.) o Inheritance by “blood” o Characteristics, not exact copies o Blending of traits o Inheritance of acquired characteristics o Similar to Darwin’s idea of pangenesis o Species are immutable o Preformationist­ drawing by Hartsoeder in 1695   Jean­Baptiste Lamarck (1744­1829) o Giraffes stretch their necks and if they continue they will  have children who have longer necks  Lysenko o Attended to transform soviet­ism  o Develop by struggling against environment  August Weismann (1834­1914) o Changes during lifetime are not a source of heritable  variation o Contrary to Lamarck ­ use­disuse (1744­1829) and  Lysenko (1898­1979)  Gregor Mendel (1822­1884) o Discrete vs. Blended inheritance o Discrete, invisible “factors” are inherited  “Factors” ­ Genes o Dominant vs. Recessive o REdiscovered in 1900 o His Experiment   Crossed tall plant with short plant and got all tall  plants. Then crossed those tall plants with each other  and some produced short plants 3:1 ratio. Tall to short  How did Mendel figure out peas were diploid? It’s the  ratio. His numbers: 787 tall, and 277 short (2.84:1)  5474 round vs. 1850 wrinkled (2.95:1)  Not really sure about that answer though.   o Law of Independent Assortment  Do certain traits tend to be found or associated with  one another  Are round peas usually yellow, or are roundness and  yellowness   Dihybrid cross 2 o  Gene?? o A section of DNA that exerts its effects on an organism  through protein or RNA products (includes regulatory  regions)   3


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