BIOS Week 3 Class Notes
BIOS Week 3 Class Notes BIOS 1300
Popular in Human Anatomy and Physiology
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This 3 page Class Notes was uploaded by Samantha Ragland on Sunday September 11, 2016. The Class Notes belongs to BIOS 1300 at Ohio University taught by Dr. Foster in Fall 2016. Since its upload, it has received 7 views. For similar materials see Human Anatomy and Physiology in Biological Sciences at Ohio University.
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Date Created: 09/11/16
BIOS1300 Week3 Lipidcomponents o Phospholipids RelativelyimpermeabletomostH2O solublemolecules andallowsfluidity o Cholesterol Strengthensto plasmamembranebymakingit less deformable Stabilizesplasmamembraneatextremetemperatures Embeddedbetweenthephospholipids o Glycolipids Located at theouterlayer Glycolipid+Glycoprotein=Glycocalyxwhichis uniqueto each person Patternofsugars is uniquetoeach person Carbohydraterichzoneoncell surface Helps preventundesirableproteininteractions Helps protectthe cell o FunctionsofLipidsinPlasma Membrane Does notdissolvewhen comes in contactwith H2O Effectivenonpolarbarriertomostsubstances Smalland nonpolarsubstancescanmovethroughthis barrierwithoutassistance Smalland nonpolarsubstancescanmovethroughthis barrierwithoutassistance Membraneproteinsperformveryspecificfunctions o Make up 2-10% ofplasmamembranebutaccount for 50% of weight in anaverage cell o There are 2structuraltypes Integralmembraneproteins Embeddedwithinplasmamembrane Amphipathic o Some are “trans membrane” Extendfrom endto end o Some are partiallyembedded Peripheralmembraneproteins Attachedtothe insideor outsideofthe surface of the membrane Couldbeattachedto theintegralproteinby noncovalentbondsremovedwithoutdisrupting membraneintegrity o Functionsofdifferentmembraneproteins Receptors Bindspecificmoleculesat cell surface Ligands-moleculesreleasedformthe cell thatbind to receptorswithinthe plasmamembraneof anothercell o ExamplesNTM(neurotransmitters)and hormones Transportproteins 2 Regulatemovementof substancesacrossa plasma membrane o Channels,carriers,and pumps Identitymarkers Proteinsor glycoproteinscommunicatetoothercells thattheybelongto thebody o Nonselfvs.self Enzymes Catalyzingchemicalreactions o Some enzymes adhereto thecell surface Cell-adhesionproteins Cell-to-cellattachment o Bindone cell toanotheror bindcytoskeleton to bilayer ProtonPump inhibitor(PPI)Prilosec(omeprazole) 1. Prilosecgets absorbedinthe bloodthroughthesmall intestine 2. Drug is nonpolarandcrossesplasmamembrane 3. Becomes protonatedincytoplasmofparietalcellof stomach 4. Prilosecchanges shapesoit fits andinhibitstheH+/K+ = ATPase pump 5. Blocks ATPso pumpcannotmoveH+ intostomachlumen 6. Over severaldays thereis a 99% reductioninacid production 3
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