Physiology Week 5 Lecture 9
Physiology Week 5 Lecture 9 IPHY 3470
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This 2 page Class Notes was uploaded by Sydney Lazzell on Wednesday September 21, 2016. The Class Notes belongs to IPHY 3470 at University of Colorado at Boulder taught by Christopher DeSouza in Fall 2016. Since its upload, it has received 11 views. For similar materials see Human Physiology 1 in integrated physiology at University of Colorado at Boulder.
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Date Created: 09/21/16
IPHY 3470: Human Physiology 1 Week 4 Lecture 8 Chalk Talk Krebs Cycle o 3 NADH, 1 FADH, 1 GTP o 6 NADH, 2 FADH, 2 GTP in one glucose molecule o 4 regulatory sites (enzymes) 1. Pyruvate à Acetyl-CoA a. PDH 2. Citrate synthesis 3. Isocitrate DH 4. a-Keto DH o Regulators 1. Substrate availability 2. Product inhibition 3. Ca2+ o PDH o (-): Acetyl-CoA, NADH o (+): AMP, Ca2+ o CS o (-): NADH, Succinyl CoA, Citrate o (+): Ca2+, Acetyl-CoA o Iso DH o (-): NADH, ATP o (+): Ca2+, ADP o a-Keto DH o (-): NADH, Succinyl CoA o (+): Ca2+ 2 Shuttle Systems o malate-aspartate o = heart o (cytosol) NADH ----- (mitochondria) NADH à 3 ATP o glycerol-phosphate o = muscle o (cytosol) NADH ----- (mitochondria) FADH2 à 2 ATP Lecture Slides Electron Transport Chain = process high energy intermediates o NADH produces 3 ATP because it moves through complex 1,3 & 4 o FADH2 only 2 ATP because it moves through complex 2 (no ATP), 3 & 4 o CoQ (complex 1&2) and cytochrome C (complex 3&4) = enzymes o Net release for 1 glucose: o Glu-Pyr(2): 2 NADH, 0 FADH2, 2 ATP o Pyr(2)-Acetyl CoA(2): 2 NADH, 0 FADH2, 0 ATP o Acetyl CoA(2)-Krebs: 6 NADH, 2 FADH2, 2 ATP § 1 NADH = 3 ATP § 1 FADH2 = 2 ATP § Total = 38 ATP o McArdle Syndrome = inability to break down glycogen o Glycogen is an important source of energy that is stored in muscle tissue o Caused by a defect in a gene that makes glycogen phosphorylase § Breaks the bonds of C1-C4, patients cant cleave bond = no glygogenolisis Lipid Metabolism o Fats are important for prolonged work, small increase in fat utilization can reduce CHO o Process of utilization is slow to activate, rates much slower than CHO metabolism (but much more ATP generated in the long run) o Triglycerides (TG) = 90% of dietary lipids, what we are breaking down when talking about lipid metabolism o Glycerol backbone o Sources: adipose tissues & diet o Esterification: making TG (fatty acid à glycerol) o Lipolysis: process of TG hydrolysis o Mobilization of TG stored in adipose tissue involves hydrolysis glycerol & free fatty acids by HSL § Free fatty acids released into blood § HSL • (-): insulin • (+): catecholamine’s & growth hormones
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