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Endocrinology - Exam 1 (Answers)

by: Michelle Notetaker

Endocrinology - Exam 1 (Answers) BIOL 4110

Marketplace > University of North Texas > Biology > BIOL 4110 > Endocrinology Exam 1 Answers
Michelle Notetaker
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About this Document

These are the answers to the first Endocrinology exam.
Dr. Harris D Schwark
Class Notes
Endocrine system
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This 4 page Class Notes was uploaded by Michelle Notetaker on Thursday September 22, 2016. The Class Notes belongs to BIOL 4110 at University of North Texas taught by Dr. Harris D Schwark in Fall 2016. Since its upload, it has received 12 views. For similar materials see Endocrinology in Biology at University of North Texas.


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Date Created: 09/22/16
Endocrinology ­ Exam 1 (Answers) 1) Which class of hormones is synthesized from tyrosine? ­ C. catecholamines 2) What type of receptor is the secretin receptor? ­ A. G protein­coupled receptor 3) Which receptor can be found in the cytoplasm in the absence of hormone? ­ D. glucocorticoid receptor 4) The insulin receptor is an example of a  ­ B. receptor tyrosine kinase 5) Intracellular receptors ­ D. (b)&(c) are correct ­ (b) may be located within target cell nuclei. ­ (c) may dissociate from chaperone proteins following ligand binding. 6) ____ binds to alpha subunits of G proteins when they are activated following  hormone binding. ­ G. GTP 7) Which receptors are bound to Hormone Response Elements, even in the  absence of hormone? ­ B. steroid hormone receptors 8) The transcription factors called STATs are activated by which class of receptor? ­ D. cytokine receptor 9) PKA (Protein kinase A) ­ A. GPCR ⍺ₛ 10)PKC (Protein kinase C) ­ B. GPCR ⍺ᵨ(<--this is a q) 11)DAG(diacylglycerol) ­ B. GPCR ⍺ᵨ 12)MAPK (Mitogen­activated protein kinase) ­ D. Receptor serine­threonine kinase 13)RAP (Receptor­associated protein) ­ C. Receptor tyrosine kinase 14)IP3 (inositol 1,4,5­triphosphate) ­ B. GPCR ⍺ᵨ 15)PKB(Akt) ­ D. receptor serine­threonine kinase 16)SMAD ­ D. receptor serine­threonine kinase 17)(T/F) Steroid hormones are stored in smooth endoplasmic reticulum. ­ False 18)An ultradian rhythm is a ­ C. rhythm with a period of much less than a day. 19)Which of the following does not act directly on gastric parietal cells to affect HCl  secretion? ­ E. (c) and (d) are correct. ­ (c) somatostatin ­ (d) cholecystokinin 20)Which of the following inhibits gastrin release? ­ D. enterogastrones from small intestine 21)(T/F) Gastrin stimulates ECL cells through a local paracrine action. ­ False 22)Which receptor mediates most of gastrin’s effects? ­ B. CCK­2 receptor 23)The presence of food in the stomach affects the release of ­ D. gastrin 24)Activation of stomach mechanoreceptors by distension plays a role in which  phase of gastric function? ­ B. gastric phase 25)Secretin and CCK are released primarily during the ­ C. intestinal phase 26)The migrating myoelectric complex (MMC) seems to be related to secretion of ­ D. motilin 27)Which hormone has enterotropic effects on the intestines? ­ D. GLP­2 28)Motilin levels are highest ­ C. during the interdigestive period. 29)Before the signal peptide is removed, a hormone is called either a   ­ Prohormone or a Preprohormone 30)Gastric mechanoreceptor activation initiates a vago­vagal reflex that results in  the release of ____ which acts on enteric neurons. ­ Acetylcholine (ACH) 31)What is the ligand for proteinase­activated receptor? ­ Pepsin 32)How do protein hormones differ from steroid hormones in terms of their storage  within an endocrine cell?  ­ Protein hormones are stored in secretory vesicles, while steroid hormones are  stored in the follicle associated with synthesis. 33)How does binding to serum transport proteins influence hormone metabolism  and hormone action? ­ Ensures that a constant supply of the hormone goes to the cells and tissues and  not lost through urine. 34)Define incretin. Liste two incretins. ­ Group of metabolic hormones that stimulate a decrease in blood glucose levels. ­ GLP­1 and GIP 35)What is the relationship between GLP­1 and Glucagon? ­ GLP­1 inhibits glucagon secretion and gastric emptying. 36)Compare and contrast Secretin and CCK in the duodenum. Include stimulus for  secretion, origin, target, and physiological effect on target cells. ● Secretin: ­ Stimulus ­ acidification of the duodenum (small intestine) ­ Origin ­ bile ducts in gallbladder ­ Targets/Effects ­ (Pancreas) ­ stimulates secretion of alkaline buffers to  neutralize intestinal pH. (Stomach) ­ inhibits gastric secretion and motility. (Liver) ­  increases rate of bile secretion. ● CCK:  ­ Stimulus ­ chyme of undigested lipids/proteins entering the intestine. ­ Origin ­ duodenum (mucosal epithelium) ­ Targets/Effects ­ (Pancreas) ­ production of pancreatic enzymes. (Gallbladder)  contraction of gallbladder. (Duodenum) ­ relaxation of hepatopancreatic sphincter.  (Stomach) ­ inhibits gastric secretion and motility. (CNS) ­ may reduce hunger.                                      ­


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