Crossing Over in Genetics
Crossing Over in Genetics ABT 360
Popular in Genetics
Popular in GENE - Genetics
This 3 page Class Notes was uploaded by Smccarty on Saturday September 24, 2016. The Class Notes belongs to ABT 360 at University of Kentucky taught by Dr. Bruce Webb in Fall 2016. Since its upload, it has received 4 views. For similar materials see Genetics in GENE - Genetics at University of Kentucky.
Reviews for Crossing Over in Genetics
Report this Material
What is Karma?
Karma is the currency of StudySoup.
You can buy or earn more Karma at anytime and redeem it for class notes, study guides, flashcards, and more!
Date Created: 09/24/16
th September 20 Notes: Linkage Analyses in Genetics Independent assortmentwhat allows you to start looking at the same chromosomes but different genes Results of this violates Mendel's law of independent assortment (coupling of sweet peas and demonstrates LINKAGE) recombination happens, if independently assorted, and spread very far from each other on the chromosome then it happens about 80% of the time. The if recombination happens between two alleles that you are tracking then you have the recombination event . More parental types happen than expected Recombination "hot spot" : recombination is likely to occur in the same spot most every time. Question in class: When is DNA is more than likely N be subject to recombination? Centromere for example Your frame of reference is what you can see, by what genes you are following. Morgan's lab, beads on a string example: but how you demonstrate that changer is happening? Corn, chromosome 9. Anyone can visual track the chromosome of that physical abnormality. Looking for the movement in the copying process. th September 20 Notes: Linkage Analyses in Genetics Problems with experiment : Pieces of chromosome could react differently, the recombination will be frequently enough and that crossing over caused recombination. Another factor : You have your genes too far apart from each other. The data doesn't indicate that they are related. Multiple crossing over: happens at meiosis I. Need to have markers, to bridge the gap or else. The data is homogenized. One of the tricks used is inversions. The result is a chromosome with two centromeres and one with none. Flipping the section, suppression or balancing chromosomes. Two point crosses: is there a way to tell where they are on the chromosome. Estimating between the gene: chromosome mapping. 50% is the highest recombination you can get, why? How many alleles are you studying? Two. To study gene order, you need more than two genes. Chromosome Mapping : Linked genes can be mapped on a chromosome by studying how often their alleles recombine. Recombination Frequency establishes genetic distance between alleles and is correlated with physical distance Calculation of map distances: parental type alleles will be the most predominant. Double recombination are much less frequent than single recombinant. Progeny number lets you figure the distance between the alleles. One can estimate the distance between genes: 2Point Testcross; Measure parental vs nonparental phenotypes Determining gene order: based upon which one is in the middle Example of a ThreePoint Test Cross Taken from the test a couple years ago. Lowest number is the double recombinant. Highest would be the parental. . P is in the middle September 20 Notes: Linkage Analyses in Genetics Parentals will be 2 highest, second is the single recombinant, third is the double recombinant: then taking those alleles and make a map. Why didn't he do the x chromosome? Cryogenic mapping: deletion mapping, and duplication mapping Impact off recombination? Occurs in every animal and it's frequencies change constantly. High radiation does can amp up the gene recombination. Heterochromatic knob First structure is abnormal, second is normal Genetic markers (WX and C) (Demonstrated that recombination of alleles involved physical transfer of parts of the chromosome) Another part of the chromosome
Are you sure you want to buy this material for
You're already Subscribed!
Looks like you've already subscribed to StudySoup, you won't need to purchase another subscription to get this material. To access this material simply click 'View Full Document'