New User Special Price Expires in

Let's log you in.

Sign in with Facebook


Don't have a StudySoup account? Create one here!


Create a StudySoup account

Be part of our community, it's free to join!

Sign up with Facebook


Create your account
By creating an account you agree to StudySoup's terms and conditions and privacy policy

Already have a StudySoup account? Login here

Nurs 329 week 1 notes

by: Mary Eke

Nurs 329 week 1 notes Nurs 329

Mary Eke
GPA 3.83
View Full Document for 0 Karma

View Full Document


Unlock These Notes for FREE

Enter your email below and we will instantly email you these Notes for Nursing Pharmacology concepts

(Limited time offer)

Unlock Notes

Already have a StudySoup account? Login here

Unlock FREE Class Notes

Enter your email below to receive Nursing Pharmacology concepts notes

Everyone needs better class notes. Enter your email and we will send you notes for this class for free.

Unlock FREE notes

About this Document

This note covers a simpler organized version of our first lectures, with relevant information
Nursing Pharmacology concepts
Dr. Godshall
Class Notes
pharmacology, peptic, ulcer, PUD, nurs329




Popular in Nursing Pharmacology concepts

Popular in Nursing and Health Sciences

This 4 page Class Notes was uploaded by Mary Eke on Monday September 26, 2016. The Class Notes belongs to Nurs 329 at Drexel University taught by Dr. Godshall in Fall 2016. Since its upload, it has received 9 views. For similar materials see Nursing Pharmacology concepts in Nursing and Health Sciences at Drexel University.

Similar to Nurs 329 at Drexel

Popular in Nursing and Health Sciences


Reviews for Nurs 329 week 1 notes


Report this Material


What is Karma?


Karma is the currency of StudySoup.

You can buy or earn more Karma at anytime and redeem it for class notes, study guides, flashcards, and more!

Date Created: 09/26/16
Drugs for Peptic Ulcer Diseases – Study guide  Peptic ulcer diseases is a group of upper GI disorders that is characterized by varying degrees of erosion of the GI wall.  It is mostly found in the lesser curvature of stomach and duodenum.  It can lead to hemorrhage or perforation  It is caused when there is an imbalance between mucosal defensive factors (mucus and bicarbonate) and aggressive factors (H. pylori, NSAID, pepsin and gastric acid) Aggressive factors Defensive factors H.pylori: gram –ve, bacteria Mucus: protects cell from acid/pepsin NSAID: stops synthesis of Bicarbonate: neutralize H+ in prostaglandins & decreases blood mucus flow/mucus/bicarb Smoking/alcohol: delays ulcer Blood flow: maintain mucosal healing and increases risk of integrity recurrence Pepsin/Gastric acid: injures cellsProstaglandins: stimulate of GI mucosa. Gastric acid activatesecretion of mucus and bicarbonate pepsin. Goals of treatment  Alleviate symptoms  Promote healing  Prevent complications: hemorrhage and perforation  Prevent reoccurrence N/B-drug therapy doesn’t alter disease process, but it create conducive environment for healing. Classes of Antiulcer drugs  Antibiotics- to kill H. pylori  Antisecretory agents- decrease secretion of acids  Mucosal protectorants: enhance mucosal lining  Antacids: neutralize acid  Antisecretory agents that enhance mucosal defenses Antibiotic drugs: should be given to patients with ulcer and confirmed infection of H pylori. None are used alone to avoid resistance.  Clarithromycin (Biaxin): causes nausea, diarrhea and distortion of taste.  Amoxicillin: kills bacteria. Works best in neutral pH  Bismuth: causes stool and tongue to be black. It inhibits growth of bacteria and yeast  Metronidazole (Flagyl): high resistance. Cause nausea and headache  Tetracycline: low resistance. Can cause stain in teeth Education: never stop taking antibiotics until completed. Treatment is complex. Side effects: nausea/diarrhea. Most patient are symptom free in 1 week. To prevent resistance, use at least antibiotics and Antisecretory agents. Antisecretory agents: production of gastric acid is stimulated by 3 compounds: acetylcholine (muscarinic receptor), histamine (acting at H2 receptor) and gastrin (acting at gastrin receptors).  Histamine Re2eptor Antagonist: promote healing by suppressing secretion of gastric acid. (-dine)  Cimetidine (tagament)- Used for gastric and duodenal ulcers healing, GERD, dyspepsia, Zollinger-Ellison syndrome and prevention of aspiration pneumonitis when given as pre-op medication. Adverse effect: gynecomastia, CNS effect, precaution with elderly-can cause confusion. Chronic use can increase risk of pneumonia. Interacts with Warfarin.  Ranitidine (Zantac): drug of choice. More potent and fewer adverse effects. No anti-androgenic effect, does not cross BBB. Antacids decrease absorption. Preferred for treating Zollinger-Ellison syndrome.  Famotidine (Pepcid): no anti-androgenic effect. Reduce dosage in renal impairment. Approved for heartburn, acid indigestion and sour stomach. Education: Do not take with antacids. Inform HCP of bleeding, No alcohol or NSAIDs, Elevate head of bed.  Proton Pump Inhibitors: most effective for suppressing gastric acid secretion. Works by irreversibly inhibiting the proton pump that generates gastric acid. Formulation include: extended release capsules, suspensions or powders. Adverse effect with short term: N/V, headache, diarrhea/constipation Long term therapy adverse effect: pneumonia, fractures, rebound hypersecretion, hypomagnesium (-prazole).  Pantoprazole (Protonix): given PO or IV  Omeprazole (Prilosec): for short term therapy of gastric and duodenal ulcers, GERD, ZES, dyspepsia. Also used to prevent stress ulcer. Only given PO  Esomeprazole (Nexium)  Lansoprazole (Prevacid)  Rabeprazole (Aciphex) Mucosal protectant:  Sucralfate (Carafate): composed of aluminum salt and sulfated sucrose. Promotes ulcer healing by forming a non-absorbent paste that protects the ulcerated lesion. Do not use within 2 hours of other medications to avoid interaction. It does not neutralize acid or decrease acid secretion. It only forms a barrier. Adverse effect is constipation. Interactions- decreases absorption of phenytoin, digoxin, warfarin, theophylline and fluoroquinolones. Education: administer on empty stomach or 1 hr. before meals and at bedtime. Watch for interactions with other medications. Antisecretory agents- enhance mucosal defenses:  Misoprostol (Cytotec): synthetic form of prostaglandin E. Only approved for prevention of gastric ulcers caused by long term therapy of NSAID. Does not prevent duodenal ulcers. It is contraindicated for pregnancy- stimulates uterine contraction. Adverse effects: diarrhea, abdominal pain, dysmenorrhea/spotting. Education: take with food, avoid when pregnant. Antacids: alkaline compounds that neutralize stomach acids. Principally indicated for PUD and GERD. Inactivates pepsin if pH is greater than 5. Enhance mucosal protection by stimulating production of prostaglandins. They increase gastric pH but not systemic pH. Also used to treat dyspepsia, heart burn, and acid indigestion. Potency is on ANC. Dosage – 7 times a  Magnesium hydroxide (milk of magnesia): used with caution for patients with renal impairment. Do not use for patients with undiagnosed abdominal pain. Causes diarrhea. High ANC  Aluminum hydroxide (Amphogel): used in patients with renal failure. Aluminum binds with PO4. It has high amount of sodium so avoid in HTN and HF patients. Has low ANC. Causes diarrhea and should be used with Mg OH.  Calcium carbonate: associated with acid rebound. Causes constipation, and eructation (belching) and flatulence  Sodium carbonate: capable of neutralizing gastric acid but doesn’t treat ulcers. Causes flatulence and belching. Can exacerbate HTN and HF so avoid in patients with history. Useful for treating acidosis and elevating pH. Education: antacids with aluminum alone can cause constipation. Magnesium alone can cause diarrhea so combine agents Maalox to balance effect. Suspension have the highest acid neutralizing capacity. Administer 1 to 3 hours after meal and at bedtime. Do not self-medicate.


Buy Material

Are you sure you want to buy this material for

0 Karma

Buy Material

BOOM! Enjoy Your Free Notes!

We've added these Notes to your profile, click here to view them now.


You're already Subscribed!

Looks like you've already subscribed to StudySoup, you won't need to purchase another subscription to get this material. To access this material simply click 'View Full Document'

Why people love StudySoup

Steve Martinelli UC Los Angeles

"There's no way I would have passed my Organic Chemistry class this semester without the notes and study guides I got from StudySoup."

Kyle Maynard Purdue

"When you're taking detailed notes and trying to help everyone else out in the class, it really helps you learn and understand the I made $280 on my first study guide!"

Bentley McCaw University of Florida

"I was shooting for a perfect 4.0 GPA this semester. Having StudySoup as a study aid was critical to helping me achieve my goal...and I nailed it!"

Parker Thompson 500 Startups

"It's a great way for students to improve their educational experience and it seemed like a product that everybody wants, so all the people participating are winning."

Become an Elite Notetaker and start selling your notes online!

Refund Policy


All subscriptions to StudySoup are paid in full at the time of subscribing. To change your credit card information or to cancel your subscription, go to "Edit Settings". All credit card information will be available there. If you should decide to cancel your subscription, it will continue to be valid until the next payment period, as all payments for the current period were made in advance. For special circumstances, please email


StudySoup has more than 1 million course-specific study resources to help students study smarter. If you’re having trouble finding what you’re looking for, our customer support team can help you find what you need! Feel free to contact them here:

Recurring Subscriptions: If you have canceled your recurring subscription on the day of renewal and have not downloaded any documents, you may request a refund by submitting an email to

Satisfaction Guarantee: If you’re not satisfied with your subscription, you can contact us for further help. Contact must be made within 3 business days of your subscription purchase and your refund request will be subject for review.

Please Note: Refunds can never be provided more than 30 days after the initial purchase date regardless of your activity on the site.