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Human genetic week 5 wednesday class note

by: linchen.deng Notetaker

Human genetic week 5 wednesday class note MCB 2400

Marketplace > University of Connecticut > MCB > MCB 2400 > Human genetic week 5 wednesday class note
linchen.deng Notetaker
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About this Document

Covering gene expression, techniques to regulate genes, including genome imprinting, RNAi, etc.
Human Genetics
Dr. Colleen Spurling
Class Notes




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This 1 page Class Notes was uploaded by linchen.deng Notetaker on Wednesday September 28, 2016. The Class Notes belongs to MCB 2400 at University of Connecticut taught by Dr. Colleen Spurling in Fall 2016. Since its upload, it has received 6 views. For similar materials see Human Genetics in MCB at University of Connecticut.


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Date Created: 09/28/16
 Ways to Silence a gene(preventing gene expression) o deacetylation o methylation  Gene expression requires o Transcription factors o RNA pol II o Open chromatin (access to the template DNA)  Epigenetics: literally “above the gene” heritable change without changing DNA sequence. o Example: methylation can be transcribed as well and passed to following generations  Genomic imprinting o Each chromosome is from paternal and maternal side. o Gene expression is affected by the sex of the parent transmitting gene  Ex: lgf2 allele is active in paternal side but silence in maternal side, because of the differential DNA methylation in male and female germ lines  The silence in different sides have different results  Parder-willi syndrome—deletion inherited from father  Angelman syndrome—deletion inherited from mother o Able to turn off specific genes  Alternating splicing increases the complexity of the genome  microRNA bind to mRNA that are not useful complementarily, attracting protein to clean these mRNA out.  RNA interference o Dicer cuts the double-stranded RNAs o Separated siRNAs bind to RISC and target mRNA o Target mRNA get cut up by nuclease and will not be able to be translated  Only 1.5 %of the genome encodes proteins, other for example: o Genes that codes non-coding RNAs(rRNA, tRNA, MicroRNA) o Introns o Promoters o Regulatory sequences


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