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Plopper Cell Biology Chapter 6

by: Taylor Swifty

Plopper Cell Biology Chapter 6 BIOLOGY 202

Marketplace > University of Missouri - Kansas City > Biology > BIOLOGY 202 > Plopper Cell Biology Chapter 6
Taylor Swifty
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About this Document

Notes from Chapter 6 in Principles of Cell Biology by Plopper
Cell Biology
Edward Gogol
Class Notes




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This 1 page Class Notes was uploaded by Taylor Swifty on Sunday October 2, 2016. The Class Notes belongs to BIOLOGY 202 at University of Missouri - Kansas City taught by Edward Gogol in Fall 2016. Since its upload, it has received 8 views. For similar materials see Cell Biology in Biology at University of Missouri - Kansas City.


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Date Created: 10/02/16
6.4 – Chapter Summary Extracellular matrix (ECM)  fills the space BETWEEN cells in multicellular organisms  integrates tissues by providing common substrate for adhesion of multiple cells  consists of hundreds of different molecules that interact in complex and highly organized ways. Two major classes of macromolecules in ECM:  Structural glycoproteins: i.e. Collagen, Elastin, Fibronectin, Laminins  Proteoglycans: i.e. heparan sulfate – gives structural stability and gives hydrophilic environment for tissues Both of these macromolecules:  consist of structural modules that mediate attachment of cell receptors, growth factors, and other ECM molecules  control cell behavior by determining 3D arrangement of cells in tissues and providing substrates upon which cells migrate At least ONE HUNDRED different proteins combine to form specialized cell surface complexes mediate attachment to the ECM and between adjacent cells. Integrin interacts with 50 of them. These complexes perform a variety of specialized functions:  Tight junctions and septate junctions  regulate paracellular transport across epithelial sheets  Adherens junctions and focal adhesions link cell surface to the actin cytoskeleton  controlling cell movement  Desmosomes and Hemidesmosomes link cell surface to the intermediate filament network  providing structural stability and distributing tensile forces across large networks


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