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Handout 6 and 7 Summaries

by: Noopur Walia

Handout 6 and 7 Summaries MCB 252

Noopur Walia

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About this Document

on our exam!!
Cells, Tissues & Development
Good, E
Class Notes
25 ?




Popular in Cells, Tissues & Development

Popular in MCBA - Cell Biol & Anatomy

This 2 page Class Notes was uploaded by Noopur Walia on Sunday October 2, 2016. The Class Notes belongs to MCB 252 at University of Illinois at Urbana-Champaign taught by Good, E in Fall 2016. Since its upload, it has received 4 views. For similar materials see Cells, Tissues & Development in MCBA - Cell Biol & Anatomy at University of Illinois at Urbana-Champaign.

Similar to MCB 252 at UIUC

Popular in MCBA - Cell Biol & Anatomy


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Date Created: 10/02/16
Handout 6 & 7 Quickies  What are the important domains the TF should have? It needs to have a DNA binding domain, It should have an activation or repression domain depending on the function of that TF  DBD + AD/RD – there are examples where a transcription factor can have more than one AD  NKFB is a heterodimer that contains P65 and P50, a TF can influence transcription by recruiting GTF for activating transcription , it stabilizes GTF as well and also has the ability to change the structures  EMSA and DNAse I for printing  Enhancer: functions very similar to the PPE with respect to the activity  Enhancer – recruits TF, both have no directionality, influences Transcription  Difference between PPE and enhancer is the size. Enhancers can be located several kB upstream or downstream of the transcription start site  Mediator complex – acts as a bridge between GTF/RNA Pol II and TF, consists of about 30 proteins  DNA has to be kept inside and also needs to be activated/repressed within a certain time window  Gene control in eukaryotes  Outer and Inner nuclear membrane, nuclear lamina, heterochromatin  A-type and B-type lamins  Caax motif  Integral membrane proteins – facilitate the stabilization of the nuclear membrane  They (lams) also interact with chromatin (mainly heterochromatin region)  2


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