Lecture 3: The Nervous System
Lecture 3: The Nervous System Biol130
Popular in Human Physiology
Popular in Biology
This 3 page Class Notes was uploaded by Alexandria Notetaker on Sunday October 2, 2016. The Class Notes belongs to Biol130 at University of California - Santa Cruz taught by Ruben,G.J. in Summer 2016. Since its upload, it has received 3 views. For similar materials see Human Physiology in Biology at University of California - Santa Cruz.
Reviews for Lecture 3: The Nervous System
Report this Material
What is Karma?
Karma is the currency of StudySoup.
You can buy or earn more Karma at anytime and redeem it for class notes, study guides, flashcards, and more!
Date Created: 10/02/16
Lecture 3: Nervous System What give a neuron its “excitable” characteristic? o all cells have a resting membrane potential that is energy stored by charge separation (electrical potential) across the plasma membrane o Na and K are unequally distributed across the plasma membrane o differences in ion concentration- chemical gradient o charge separation- electrical gradient o charged ions intracellular vs. extracellular- electrochemical gradient *electrical neutrality on both sides is kept magnitude of resting membrane potential varies with cell type (-5 to -100 mV) o neurons often average around -70 mV Ion Channels regulate movement of ions across the plasma membrane o Leak channels: always open, unregulated diffusion o Gated channels: open and closed states, regulated diffusion Resting membrane potential depends on 2 things 1) Differences in concentrations (intra/extracellular fluids) 2) Differences in membrane permeability Equilibrium potential is the electrical potential necessary to balance a given ionic concentration gradient across a membrane so that the net flux of the ion is zero Nernst Equation o E ion 61/Z log (C /out in o Goldman-Hodgkin-Katz (GHK) equation accounts resting membrane potential with multiple ion concentrations Clinical Issues o Hyperkalemia- Increased K levels in the blood (extracellular) Caused often by kidney failure o Hypokalemia- decreased K levels in the blood Caused often by severe diarrhea, vomiting, diuretic use
Are you sure you want to buy this material for
You're already Subscribed!
Looks like you've already subscribed to StudySoup, you won't need to purchase another subscription to get this material. To access this material simply click 'View Full Document'