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MCB2210 week 6 monday notes

by: linchen.deng Notetaker

MCB2210 week 6 monday notes MCB 2210 001

linchen.deng Notetaker
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About this Document

Covering the mechanism about the import and export of protein to the nucleus regulation of transportation of proteins
Cell Biology
David Daggett (PI)
Class Notes
Cell, Biology
25 ?




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This 2 page Class Notes was uploaded by linchen.deng Notetaker on Monday October 3, 2016. The Class Notes belongs to MCB 2210 001 at University of Connecticut taught by David Daggett (PI) in Fall 2016. Since its upload, it has received 4 views. For similar materials see Cell Biology in MCBA - Cell Biol & Anatomy at University of Connecticut.

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Date Created: 10/03/16
MCB2210 Week 6 Monday Nuclear localization signals and nuclear export signals  Importins and exportins are receptor proteins that carry proteins into and out from the nucleus Small G protein called Ran binds to receptor proteins in the nucleus so  cargo proteins transported in are released in the nucleus  protein complex can be exported to the cytoplasm and be released Ran present in GTP form in the nucleus(due to GEF) and GDP form in cytoplasm(due to GAP) In general, GEF activates G proteins and GAP inactivates G proteins Ntf2 is an import receptor for Ran  Ntf2 bind to Ran-GDP in the cytoplasm to direct it back to the nucleus to be phosphorylated by GEF FG repeats at the nuclear pore complex direct proteins through the pores so they are crucial for transport trough the nuclear pores  Most RNA species are exported via nuclear pores (mRNA, tRNA, rRNA, ribosomal subunits)  Different exportins are needed to finish different transporting task  There are different exportins for different RNAs:  Labelled and unlabeled tRNA compete for the exportins  U1 snRNA do not show competition for the exportins  Thus they are different exportins Transport of proteins through nuclear pore can be regulated  T cell activation with transcription factor(NF-AT) o When Ca2+ concentration increases in the cell, calcineurin( phosphatase) activates the import of NF-AT by cleaving phosphate groups from NF-AT o NF-AT binds to DNA, initiates T cell expression o When Ca2+ concentration decreases, calcineurin is removed and phosphate groups are added to NF-AT, preventing binding with DNA, inactivating T cell expression  Stereo receptor o Steroid hormones diffuse through cell membrane o Hormones bind to receptors, causing conformation change of receptor proteins o Receptor proteins are imported into the nucleus and activate gene expression


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