Microbiology 251 chapter 13 Viruses
Microbiology 251 chapter 13 Viruses 251
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This 5 page Class Notes was uploaded by Jessica Torres on Friday October 14, 2016. The Class Notes belongs to 251 at College of Southern Nevada taught by Heidi Porter in Fall 2016. Since its upload, it has received 29 views. For similar materials see 251 microbiology in Microbiology at College of Southern Nevada.
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Date Created: 10/14/16
chapter 13 Viruses 10/14/2016 ▯ Viruses are ▯ -smaller than bacteria ▯ -able to cause human diseases ▯ - able to destruct bacteria ▯ ▯ active= live ▯ can reproduce if placed in a host ▯ inactive=dead ▯ have permanently lost the ability to reproduce ▯ latent = not currently reproducing but still have the ability to reproduce ▯ ▯ Infectious particle, not a cell (no cell membrane) ▯ ▯ How big is a virus? ▯ 2000 viruses fit into a bacteria cell ▯ 50 million fit into a human cell ▯ ▯ General Lifecycle ▯ 1. virus lands on cell ▯ 2. virus injects the cell ▯ 3. host copies the virus DNA/RNA for it ▯ 4. Virus leaves and host dies ▯ 5. virus finds new host ▯ ▯ Naked virus ▯ Contains nucleic acid ▯ Surrounded by a capsule ▯ ▯ Enveloped virus ▯ Also contains nucleic acid surrounded by a capsule Capsule has an “envelope” around it which contains spikes Every capsule has spikes, they are just protein Envelope is composed of phospholipid bilayer that is stole from its last host Spikes come from viral genes Genetic Core DNA or RNA Single strand or double strand Linear or circular Whole or segmented Can have multiple copies per virion Virion vs. Virus Virion= outside/ between cells Virus= inside host Genome Between 2-900 genes HIV(9 genes) Capsid Protein coat Individual units called capsumers ex. Links in a chain Life Cycle of Animal viruses Adsorption (sticks to surface) Penetration of cell Replication of genetic material Synthesis of protein Assembly Release from cell Attachment or adsorption Interaction between receptors on host cell and glycoprotein/ protein on viral surface Envelopes spikes or protein on capsid Tropism Penetration Endocytosis – engulfment virus in vesicle vesicle, envelope, capsid break down free DNA Membrane fusion – becomes part of cell membrane Only envelope viruses can do this Direct penetration – drills a hole injects their DNA Not common Biosynthesis Replicates its own genetic material Synthesizes enzymes and capsid DNA viruses replicate in nucleus DNA viruses generally use the host replication machinery RNA viruses replicate in cytoplasm RNA viruses generally bring their own replication enzyme Ingredients of protein synthesis Genetic material Enzymes to do transcription Ribosomes tRNA amino acids energy ATP What protein does a virus code for? Capsid protein Enzymes – replicate of RNA –escape – manipulation of the host Spikes (protein) Assemble Self assemble Scaffolding protein (holds while being assembled) – viral/ host proteins Spikes in host membrane ▯ ▯
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