Brain&Behavior PSY 3120
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This 10 page Class Notes was uploaded by an elite notetaker on Monday August 31, 2015. The Class Notes belongs to PSY 3120 at Wayne State University taught by Thomas Fischer in Fall. Since its upload, it has received 19 views. For similar materials see /class/165472/psy-3120-wayne-state-university in Psychlogy at Wayne State University.
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Date Created: 08/31/15
Lecture 4 1042012 64600 PM Goals for Today How to create action potentials o quotThe signalquot to communicate in synapsis o Ionic basis of the quotdecisionquot The process of synaptic transmission o How on neuron can change the voltage of another o Go from chemical signal to electric and back The major neurotransmitters of the brain o List major players o Action Potential Is when the SOMA adds together grading potentialsl o Hyperpolar negative 0 Depolar positive 39a A gvaaed manual suns above quotusan I a us Imllallan pow am am sea n mnng cm can body N m mggorm39 isan mshnld and human docs nui um an anion pox yum EWEU 5mm comm 1 below News No acmn WWIva Tennral lime and SDalial Snace Summalinn Graded nnlenlials decay Potentials shelf life is short must be added to before it disappears meaning you can no longer add to it Neurons are 3D graded potentials come from different places on dendrite This can be an issue when inputs are spaced far apart Because GP39s decay Threshold Add grading potentials are voltages that are added together Threshold is a level of voltage in a cell Always more positive than resting potential You reach the threshold and you get an action potential every time All or None Law An action potential is either ALL there or NONE there Depends entirely on whether or not you meet threshold or not Ionic Basis of Action Potentials The power of the battery lies in Na Na is very badly out of equilibrium The forces that are pushing Na is the focus Voltage gated Na gates open Na rushes in very quickly Before Na goes into cell K is inside the cell and resting happily After Na floods into the cell BOOM when Na enters voltage shoots up K leaves the cell due to electrical repelling forces When K leaves the cell thats when AP spike goes back down Steps to create action potential Reach threshold Open voltage gated Na channels Na channels close right after the rush Refractory can39t be opened again for some varied period of time K leaves the cell NaK pump shovels Na out at the expense of bringing 2 K in for every 3 Na kicked out This all prepares for another action potential Terms to know 9 conductance Refers to the flow of current through the channel If channel is open it has good 9 If channel is closed there is no 9 Equilibrium Potential The voltage of a neuron any ion is at equilibrium Propagation Means to reproduce This is why AP stays the same size Na spreads along the axon Axon is fluid Ions spread through fluid like food coloring Now Na can reach point B and depolarize to reach threshold kind of like a wave or fire on a fuse Always moving forward Myelin insulates the axon in blobs Nodes of Ranier Where there is no myelin spreads out points of ignition on axon fuse Forces AP to travel in myelin and JUMP in nodes JUMPS help speed process And Saves Energy Synapse Module 32 pg 60 Depolarize will open voltage gated Ca channels Calcium causes vesicles to fuse to membrane Crosses the gap and binds to receptors on the post synaptic cell the receptors do the conversation from electrical to chemical chemical binds to receptors that creates a graded potential that brings it back to electrical Postsynaptic potentials graded potential caused by the release of neurotransmitters IPSP hyperpolar Cl channel opens makes cell more negative inhibits AP generation Cl floods into the cell adding in the cell brings charge way too neg to reach thresh EPSP excititory depolar creating an AP Na coming into the cell adding in the cell closer to threshold Terminating transmission Chemical Degadation job is to destroy neurotransmitter Reuptake most common way to terminate Neuron takes neurotransmitter back to be used again Transporter Senses NT in the gap it sucks it back into the cell Neurotransmitter Ionotropic FAST Ion channel with receptor attached directly to it They are the same thing ultimately So channel opens very quickly Metabotropic SLOW Receptor and channel are different units NT binds to receptor causes a chemical reaction within the cell Second message Second message goes from receptor to the channel FastSlow potentials Ionotropic Faster onset and decay miliseconds Metabotropic Slower onset and longer lasting seconds Keeps cell nearer to Thresh EPSP so you can excited faster and with less effort MAJOR neurotransmitters Amino acid receptors are primarily ionotropic Glutamate EPSP Main fast excitable neurotransmitter GABA IPSP Main fast inhibitor neurotransmitter Acetzchoine has both ionotrogic and metabotropic receptors Ionotropic quotnicotinicquot nicotine Nervemuscle junction Metabotropic quotmuscarinicquot in the brain especially the cortex Important for learning makes it easier to learn Monoamine receptors are mostly metabotropic Serotonin Dopamine Norepinephrine Epinephrine Monoamine receptors are mostly metabotropic Slow regulation of brain activity important for arousal and mood Your mood changes slowly YOUR BRAIN IS LIKE A CHEMICAL SOUP YUMM 1042012 64600 PM 1042012 64600 PM 1042012 64600 PM 1042012 64600 PM
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