8/31-9/2 Notes PSY 315 - M001
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This 6 page Class Notes was uploaded by Christy Kalebic on Thursday September 3, 2015. The Class Notes belongs to PSY 315 - M001 at Syracuse University taught by T. Palfai in Fall 2015. Since its upload, it has received 70 views. For similar materials see Drugs and Human Behavior in Psychlogy at Syracuse University.
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Date Created: 09/03/15
831 Psychopharmacology Psyche soul mind body Pharmakon cure poison drug Logos speech conversation study Pharmakos sacri ce of cure Pharmacy drugs the science of compounding drugs De nition the study of drugs that affect behavior Drug substance other than food with biological action Psychopharmacology studies 0 All aspects of drugs history mechanism use abuse short and long term effefts 0 Chemical basis 0 Mental illness 0 Teratology on test the study of monsters offspring The history of drug use 0 Who uses drugs 0 Reindeer llamas goats robins people 0 Where did people start 0 The Americas mushrooms 15000 BC 0 Alcohol 10000 BC 0 First record of opium 4000 BC 0 Asia cannabis use 2000 BC 0 Who used it o Odysseus greek mythology moly herb 0 Rome Dioscorides oldest book of herbals 0 Medieval Europe witches 92 History Friedrich Serturner 17831841 0 1803 isolating morphine 0 rst alkaloid chemist JJ Moreau de Tours 18041884 DAWAMESC 1845 o Pistachio vanilla hashischs Club de Hashichins Hotel Pimodan Lauzun 1860 cocaine Albert Niemann 1893 amphetamines 1938 LDS Albert Hofmann 1951 Birth of psychopharmacology Laborit Charpentier Delay 19505 Tranquilizers 19605 sedatives and anxiolyticsanxiety l decrease mental institution population 19705 endogenous receptors 19805 designer drugs and crackiquid form stronger base free up no salt 19905 mood and personality pills Prozac antidepressants 20005 pharmacogenetics personalized drugs based on genetics 20105 delivery systems Drug substance with biological action 0 Determinants of biological action 0 Drug receptors Receptor site Neurotransmitter Ag Agonist activates cell acts as neurotransmitter At Antagonist blocks cell a Competitive competes for site with neurotransmitter n Noncompetitive blocks cell somewhere else How do enzymes work E enzyme protein E terminates the action of Ag therefore E is an endogenous At If drug X blocks E drug X is an indirect Ag If drug Y facilitates the action of E drug Y is an indirect At Reference to the original receptor determines Ag or At status 0 Administration Site of administration shoulder leg Route of administration pill injection n Oral voluntary or tubing 0 Easy 0 Slow Able to pump stomach n Injection 0 IV intra venous 0 Fast 0 Cannot pum out o A intra atrial IMintra muscular 0 Absorption good 0 SC subcutaneous 0 Skin pumping 0 IP intra peritoneal 0 Into abs intestines ITintra thecal 0 Into nerve tissue 0 IC intra cranial a Surface 0 Cream ointment n Inhalation Vapor smoke a Suppository Rectal vaginal Site of action where drug action take place brain Drug forms solid liquid volatile Drug vehicle the carrierdissolving substance oi saline Body compartments space enclosed by membrane 0 Absorption Site of administration site of action Sometimes peak blood levels What determines absorption In A drug s ability to cross biological membranes In Biological membranes are semipermeable The uid mosaic model a Drug must go through fatty tissue a Passive transport sma drug a Active transport How can a drug moecue cross membranes In Size pores n Soubiity l waterwill not cross membrane vs lipid n Ionization l biological compartments n Polarization n pH alkaline vs acid ion trapping stomach 32 0 blood 74 0 Distribution 0 Drug fate What happens after drug activated 0 Dosage o Nonspeci c factors Tolerance Gender
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