Biochemistry Biosynthetic and Energy Metabolism and Its Regulation
Biochemistry Biosynthetic and Energy Metabolism and Its Regulation CHEM 153C
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This 3 page Class Notes was uploaded by Michael Reilly on Friday September 4, 2015. The Class Notes belongs to CHEM 153C at University of California - Los Angeles taught by Staff in Fall. Since its upload, it has received 123 views. For similar materials see /class/178004/chem-153c-university-of-california-los-angeles in Chemistry at University of California - Los Angeles.
Reviews for Biochemistry Biosynthetic and Energy Metabolism and Its Regulation
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Date Created: 09/04/15
FALL 2005 CHEM 153C DISCUSSION OCTOBER 6 2005 GLYCOLYSIS AND TCA CYCLE REVIEW Summary of Important Concepts I GLYCO LYSIS CYTOSO L Intermediates and their structures enzymes cofactors Irreversible steps sites of regulation Hexokinase PFK1 Pyruvate kinase ATP equivalents produced 2 ATP 2 NADH 8 ATP equivalentsglucose Fates of Pyruvate 1 Pyruvate 9 AcetyICoA 002 9 3 002 2 H20 Aerobic glycolysis Maintains NADNADH 2 Pyruvate 9 Lactate Anaerobic glycolysis Lactic acid fermentation levels 3 Pyruvate 9 Ethanol 002 Alcoholic fermentation yeast only Regulation of Hexokinase PFK1 Pyruvate kinase Activated by AMP low energy charge Inhibited by ATP high energy charge II TCA CYCLE MITOCHONDRIAL MATRIX Intermediates and their structures enzymes cofactors Irreversible steps sites of regulation Pyruvate DH complex Citrate synthase lsocitrate DH u ketoglutarate DH Components of Pyruvate DH complex and their functions ATP equivalents produced 4 NADH 1 FADH2 1 GTP 15 ATP equivalentspyruvate 0arbon tracing and analogous reactions Stereospecificity of aconitase Regulation of Pyruvate DH complex 0itrate synthase lsocitrate DH dketoglutarate DH Activated by AMP low energy charge Inhibited by ATP high energy charge 0ther allosteric effectors FALL 2005 CHEM 153C DISCUSSION ATP PRODUCTION IN GLYCOLYSIS TCA CYCLE AND OXIDATIVE PHOSPHORYLATION W 15 1 and Initiative Phasphorylatlon Stoichiometry of Eoemzyme Reduction and ATP Formation in the Aerobic QIidatidn of Glucose via Glycaiysis the Pyruvate Dehydmgenase Reaction the Citric Acid Cycle Number in IITF or reduced coenzymes direcliy Number In MP Reaction formed ultimately formed39 39Giuwsu s glutus tI llwpii39diil 1 A1 P 1 Fructcrse Elpi lDSpl39li JEE lruIL39iiJse Ltwbiaplmaphale I M P J E Glycemidehyde 3pl1u5ph3lia 2 13hisphJ phnglyceraie 2 NADH 3 5 9 13Blsphosphuglycerale 392 3phosphugiytefate 2 ATP F Phosphmnnlpyruvate v P pyru39rate 9 ATP 9 E Fynwate w 2 shawlCCA 2 NADH I launi39iraie a E rrHEECEILaiarai39E 2 NADH 5 2 rm l fmmlutamie a 2 sur39czimIACQA 2 NADH 239 S iml Can 2 51 mate 2 r iTP or GTPII 2 Succnnate 2 iumarate 2 F DH 3 Malaria maiuaruluiu 2 NM 5 7 Total 30 32 l ln39 IE EaILLlated as NF per NADH anI 15 HP par FlamL a negative value Inclsates mrIturnntlnh Source Lehninger Principles of Biochemistry 4th Edition Nelson and Cox NOTE 0 In this course we will use 3 ATP per NADH and 2 ATP per FADHZIQHZ 0 Our course textbook Biochemistry 3rd Edition Voet and Voet uses these designations FALL 2mg cum 153 mscussmN BchnLvswslcwnsnL m mndmm uvdu i3 7 unmmwwgmm a wn wm mum m V w Wusm uww m ammmmw W mm nme a uim i39squot lm 1 un wwwm 4393 0 m Eu 1quot w mm WC u mumbm m w a 2 r r WWW W Mam Source Lehmnvev vac v es mamcmm mm Nebanand m 3
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