Drug Interactions 81.0
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This 2 page Class Notes was uploaded by Arielle Reiner on Saturday September 5, 2015. The Class Notes belongs to 81.0 at University of Pittsburgh taught by Fanselow,Erika in Fall 2015. Since its upload, it has received 63 views. For similar materials see DRUGS AND BEHAVIOR in Neuroscience at University of Pittsburgh.
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Date Created: 09/05/15
Drug interactions 0910412015 Antagonism Potency or ef cacy of a drug can be altered by the presence of another drug or substance Additive summation 0 Presented together is the sum of the 2 drugs Synergism o 2 drugs together are more potent andor ef cacious than either drug given alone Cannot say what effect a drug will have unless you specify the dose and the route of administration There may be different dose response curves depending on the effect monitored Larger doses of a drug do not necessarily mean larger responses Interactions with other drugs must be considered Comparing dose response curves for intended effects side effects and lethality can suggest proper therapeutic doses Ligands affect neurons by changing the shape of receptors 0 Ligands t into speci c binding sites on a receptor molecule 0 When a ligand is bound the receptor changes shape conformational change which allows it to affect the neuron it is part of c When the ligand leaves the binding site the receptor goes back to its original shape and is thus inactive o The binding of the drug and the conformational change are both NOT permanent More active receptorsmore effect of the drug 0 When a drug or neurotransmitter binds to a receptor this affects the neuron that has the receptor in its cell membrane 0 The amount of the effect a drug has depends in part on how many receptors are activated have drug molecules bound to them at a given time General principle o The more receptors that are active at a given time the more a neuron is in uenced by a drug Ligands eg drugs can be attracted to binding sites with different strengths Affinity o The strength with which a ligand is attracted to a receptor binding site More drug moleculesmore activated receptorsmore effect of the drug A higher af nity means more receptors will be activated at a given time If molecules are more drawn to receptors the drug is potent and you need a lower dose to attain the same effect as a less potent drug that you would need a higher dose of
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