Exam 1 Week 1- Basics of Virology/Ebola Introduction
Exam 1 Week 1- Basics of Virology/Ebola Introduction MICROBIO 640
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This 2 page Class Notes was uploaded by Aparna Pal on Sunday September 6, 2015. The Class Notes belongs to MICROBIO 640 at University of Wisconsin - Madison taught by Nathan Sherer, Robert Kalejta, Paul Ahlquist in Summer 2015. Since its upload, it has received 86 views. For similar materials see General Virology in Microbiology at University of Wisconsin - Madison.
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Date Created: 09/06/15
WHY STUDY VIRUSES HIVAIDS Hep BC infects 3 of global population Rabies used to discover basics of cell and molecular biology APPLICATIONS OF VIRUSES Gene transduction used in gene therapy ex used to make better Cytotoxic T cells for more efficient cancer therapy ABOUT THE VIRUS Virus coined by pasteur when examining rabies quotpoisonquot may include a cell derived lipid envelope CAPSID protein shell of nucleic acid protectionorganization VIRION the TAXI the VIRUS Nucleic acid component travels in VIRUSES OBLIGATE INTRACELLULAR PARASITES complete dependence on host for replication due to small genome size 4250 kb cell has 3E7 kb in humans Evolutionary advantages genetic efficiency dense overlapping genes multifunctional proteins host exploitationability to hijack host machinery for viral genome replication PROPERTIES OF A VIRUS infectious obligate intracellular genome directs host machinery through viral replication virions form by self assembly within host transmission within virion signals next infectious cycle VRUSES can multiply VIRIONS cannot the virion is the taxi cab of the virus VIRAL PROPOGATION Delivery attachment and entry Decoding viralcellular polymerase transcribes viral nucleic acids translation by host ribosome Replication transcription of new genome Release assembled particles leave MEASURING VIRAL REPLICATION Plaque assays use serial dilutions to find a meaningful PFUmL othenNise too many to count VIRAL GROVVI39H Eclipse phase intraextracellular number do not change when virus invades and activates latent extracellular virus found first infection phase highly infectious viruses will have lower ParticletoPFU ratios Multiplicity of infection number of virions infecting a population Low MOI allows for several infection cycles EBOLA 8 genes targes liver and immune cells macromicroscopic bleeding found in fruit bats pigs dogs nonhuman primates first outbreak in west africa fruit bats may be new vectors as west africans had consumed them as a delicacy traditionally poor follow through infrastructure little understanding of protocol on grassroot level later on manned less what is the host response difference between survival and succumbents studies plasma metabolomics and lipidomics isolate exosomes microRNAseq Cytokine ELISAs PBMCs ceHlayer Goals in Sierra Leone Host response Evolution of the genome is the virus evolving with the treatments are healthcare providers seroconverting to give more immunity to infection
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