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Comp Functional Genomics

by: Ashleigh Dare

Comp Functional Genomics ECS 234

Ashleigh Dare
GPA 3.75


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This 9 page Class Notes was uploaded by Ashleigh Dare on Tuesday September 8, 2015. The Class Notes belongs to ECS 234 at University of California - Davis taught by Staff in Fall. Since its upload, it has received 16 views. For similar materials see /class/187796/ecs-234-university-of-california-davis in Engineering Computer Science at University of California - Davis.

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Date Created: 09/08/15
ECS 234 Lecture The Genome and Biotechnologies P H Liu Colored boxes indicate post mstmhr derrickIs of expression gene n f I GSK3MFIa Mesa1an Hindum lVV l 39x m y K111 x 39nrnmgiy n have a GavelMI 100pb Today Basic Molecular Biology Genes Proteins etc Genomes Central Dogma Observing the Central Dogma PCR amplification DNA Sequencing genome Microarrays transcriptome ChlP Protein DNA interactions Yeast TwoHybrid Protein Protein Interacts Biological Preliminaries Life is survival of information Properties of life Information exchange communication Procreation passing on information Evolution change A machine that s set in motion and never stops Preliminaries Topdown Organization of life Social groups etc Organisms Species etc Organs Tissues Cells units of life Organelles etc Molecules of life DNA RNA proteins Preliminaries 7 M Inheritable information 7 Units of Inheritance genes regulatory regions 7 Proteins Daytoday footwork 7 Both are complex polymer molecules DNA String over the alphabet ACGT AT an Genes to Proteins 5 C can U4 A c cm a s A cm s c u cm u c a Co ms 6 A We C u m 5 Ribonudsh and vs GCG mahgril r 39 Emly 39r i Viruses Dnly w A In all Lwn lg Sells Pmtain L n LD39HE39T Lu39le Forms 4 39 DNA p IRMA Biological Information How Genomes Organization and complexity Genomes are the union of all DNA in an organism there are different types of DNA nuclear and mitochondrial Only small 2 of the human genome is genes The rest contains various promoter regions and junk gt50 Genome sizes vary among organisms shortest for Phages and Viruses longest for mammals and some plants figure from Baldi


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