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by: Mikaela Maldonado

BMSWeek6Notes.pdf BMS 260

Mikaela Maldonado
GPA 4.0

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About this Document

All rights go to Dr. Anthony but all material is my own
Biomedical Sciences
Dr. Russell Anthony
Class Notes
25 ?




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This 3 page Class Notes was uploaded by Mikaela Maldonado on Tuesday March 1, 2016. The Class Notes belongs to BMS 260 at Colorado State University taught by Dr. Russell Anthony in Spring 2016. Since its upload, it has received 37 views. For similar materials see Biomedical Sciences in Biomedical Sciences at Colorado State University.

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Date Created: 03/01/16
Muscle Physiology ***Myocyte or myofiber is a muscle cell Skeletal  Voluntary  Multinucleated  Long, linear  Striations Smooth  Involuntary  Spindle shaped Cardiac  Intercalated disks  Striations  Uninucleated  In between voluntary and involuntary  Glycogen  Branching Skeletal Muscle Fiber  Multinucleated  Lots of mitochondria  Transverse tubules  Myofibrils – contractile units o Give striated appearance o Ordered arrangements of myosin (thick) and actin (thin)  Sarcomeres o From one Z line to the next forms the contractile unit o Each z line is a non contractile unit  Sarcolemma – aka the plasma membrane o Invaginations in sarcolemma are part of transverse tubule structure  Sarcoplasm – aka the cytoplasm  Sarcoplasmic reticulum – like the smooth ER, functions to store Ca+ ions  Epimysium-outer connective tissue sheet, at ends forms tendons  Perimysium – surrounds individual muscle bundles  Endomysium – surround individual myocytes  Invervated at a 1:1 ratio Structure: Titin – achors actin to Z line (non contractile) I band – actin, titan, z line (light) A band – myosin, actin (dark) M line (junction between H zone – thick and thin filaments slide past one another Sliding Filament Model  Displays molecular mechanisms  Shortening does not correlate with contraction  Activation of cross bridge filaments -> propel the thick and thing structures to move past one another  Myosin o Heavy and light sections o Heavy is the globular head and filament o Actin binding site is available o Globular head  Functional ATPase (ATP->ADP+Pi)  Activity of myosin filaments ratcheting to move actin filaments  When ATP binds to myosin the actin and myosin interaction is disrupted  Immediately causes ATP -> ADP  Myosin head carries ADP + Pi and is chared  Myosin binds to actin causing the release of Pi  Allows myosin head to pivot and ADP is release  Actin o Globular actin that polymerizes into filaments o 2 stranded alpha helix that is similar to beads on strings that are wrapped around one another o contractile protein o G actin has a binding site for myosin  Tropomyosin o Regulatory protein o Overlap binding sites on action for myosin and inhibits interaction when in relaxed states o Forms a strand that wraps around actin  Stearic blocking model o Physically blocking by tropomyosin o Chemical and physical conformational blocking takes place  Troponins o Troponin C – binds Calcium – tethers to others to create a conformational change in both troponins – location is in the middle of troponins o Troponin I – binds actin o Troponin T – binds tropomyosin  Calcium is released from the sarcoplasmic reticulum o Resting 10^-7 M o Stimulating 10^-5 M


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