Last Lecture before Exam 2
Last Lecture before Exam 2 BIOL 30603
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This 2 page Class Notes was uploaded by Mallory Notetaker on Wednesday March 2, 2016. The Class Notes belongs to BIOL 30603 at Texas Christian University taught by Dr. Akkaraju, Dr. Misamore, Dr. Chumley, Dr. McGillvray in Spring 2016. Since its upload, it has received 41 views. For similar materials see Molecular, Cellular, and Developmental Biology in Biology at Texas Christian University.
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Date Created: 03/02/16
Cell Bio Notes 2/2/16 -Macrophages make the vascular stuff really permeable for other things to come in (this causes swelling) -it also recruits other cells to come help attack pathogen The neutrophil -Sometimes called PMNC (polymorphonuclear cells) -Nuetrophils make up the largest percentage of circulating cells in the blood Phagocytosis -Primary and secondary granules- are part of the neutrophils, proteins held together by poly saccharides and glycoproteins, they are not in the membrane, just a solid chunk of protein that interact with each other and the pH needs to change for them to be released, as long as you have granules you can kill pathogens -Oxidative Burst- the neutrophils start consuming large amounts of oxygen -Neutrophil extracellular traps (NETS): another way you can kill is by dumping out your chromatin Neutrophil rolling-rolling along the vascularature until they reach a site that has additional adhesion, this increases until it gets closer and closer to the site of infection -this can happen because cytokines are released and allow the epithelial cells to express different adhesion molecules Neutrophil Diapedesis- pushes its way into the tissue -Chemotactic- chemically driven type of cells -Enﬂammed epithelial cells express chemokine to allow for adhesion Granules in Neutrophils are what kill the pathogen -there are receptors on the neutrophil that -A number of receptors help mediate phase cytosine by neutrophils -Toxic granules within the neutrophil help destroy the bacteria or fungus NETS Neutrophils either die by apoptosis and are then phagocytose by macrophages, or -Netosis - nucleus swells, bursts, an chromatin is released, along with antimicrobial peptides bound to the DNA -anything that happens to be left over (chopped up DNA?) it gets stuck on the granules -Question on test is on Netosis -Transporter protein (TAP) -Cytotoxic T cell only recognizes 1 cell in MHC class 1 -Macrocell makes synapse with T cell -secretions from the t cell get in the synapse and are cytotoxic and kill the macrophage -The target cells is killing itself by apoptosis while the t cells are dumping cytotoxic chemicals in it also -The t cells are recognizing the MHC on the cells but they can’t kill it because there is not enough peptide -every cell in your body has MHC class 1
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