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This 2 page Class Notes was uploaded by Renee Lehner on Wednesday September 9, 2015. The Class Notes belongs to BIOL 200 at University of Washington taught by Staff in Fall. Since its upload, it has received 10 views. For similar materials see /class/192333/biol-200-university-of-washington in Biology at University of Washington.
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Date Created: 09/09/15
III Lipids and Biological Membranes Lecture Outline 3 Lipid Chemistry A Why was enclosure of the first selfreplicating molecule key to biological evolution B De nition of a lipid What is the difference between a hydrocarbon and a fatty acid C Three important lipids found in biological systems steroids phospholipids and fats D How do the phospholipids found in the three domains of life differ E Lipids that form membranes are amphipathic What does the word amphipathic mean Membrane Structure and Function A Formation of lipid micelles bilayers and liposomes What are planar 03 0 U membranes Selective permeability of lipid bilayers 1 What types of molecules can cross membranes and what accounts for this selective permeability 2 Effect of saturated and unsaturated hydrocarbons on membrane permeability 3 How does the presence s of steroids and hopanoids change membrane permeability 4 Affect of temperature on permeability Diffusion Does diffusion create a unique intracellular environment What is osmosis What is meant by low water activity or availability How do prokaryotes survive in low water availability environments Creating a Unique Environment Membrane Transport proteins A 003 U P1 7391 Amphipathic proteins and the Fluid Mosaic Membrane Model of Singer and Nicolson 1970 Ionophores vs ion channels Facilitated diffusion Is there a common way to transport glucose among all organisms ie Eukaryotes vs Prokaryotes Active transport 1 Sodiumpotassium pump or the NaKATPase 2 ABC ATPbinding cassette transport systems 3 Major facilitator superfamily of transport proteins Group Translocation Why is this not considered an active transport mechanism You should know differ between the various transport mechanism ie is it unique to prokaryotes or eukaryotes or both and what is energy source and is molecule being transported modified or not 1 Building Blocks of Macromolecules and properties of macromolecules Lecture Outline 2 Building blocks for macromolecules Amino Acids i basic structure and properties of amino acids What is the signi cance of amino acids becoming ionized ii What properties can be used to separate amino acids into 3 groups iii Optical isomers of amino acids Chirality iV What is meant by an essential amino acid B Sugars i What functional groups de ne a sugar ii How do sugars differ from one another iii What type of bond holds sugar molecules together C Lipids will be discussed in separate lecture D Nucleotides 1 basic structure of nucleotides What is difference between a nucleoside and a nucleotide ii What are the nucleotides that comprise RNA and DNA Condensation polymerization of building blocks into macromolecules A Proteins i What is a peptide bond ii What determines the primary secondary tertiary and quaternary structure of proteins iii What factors in uence the structure of proteins iV What role do molecular chaperones have B Nucleic Acids i Nucleotides are covalently linked to one another through a phosphodiester bond ii What is meant by a polynucleotide strand haVing a 5 and a 3 end iii In what direction is nucleotide sequence read iV Complementary basepairing between nucleotides V What type of forces hold basepairs together Vi RNA as the first selfreplicating molecule Ribozyme vs replicase Why not DNA or protein
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