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General Genetics

by: Carol McDermott

General Genetics MBioS 301

Carol McDermott
GPA 3.59

Julie Stanton

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Julie Stanton
Class Notes
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This 3 page Class Notes was uploaded by Carol McDermott on Thursday September 17, 2015. The Class Notes belongs to MBioS 301 at Washington State University taught by Julie Stanton in Fall. Since its upload, it has received 46 views. For similar materials see /class/205936/mbios-301-washington-state-university in Molecular Biosciences at Washington State University.

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Date Created: 09/17/15
Study Questions General Genetics For Comprehensive Portion of Final Exam ONLY Section One 1 Describe the Watson and Crick model of the structure of DNA How does RNA structure differ from DNA structure 2 What is the major limitation of DNA polymerase Explain how this effects DNA replication 3 Describe the process of DNA replication including initiation elongation and termination 4 Explain what happens during leading and lagging strand synthesis What are Okazaki fragments How is synthesis on both strands coordinated 5 What is the end of chromosome problem in eukaryotes How does telomerase add telomeric sequences to DNA ends 6 What is a promoter Describe the features of promoters in prokaryotes and eukaryotes Distinguish between the three eukaryotic RNA polymerases 7 Describe the process oftranscription including initiation elongation and termination 8 Describe how a eukaryotic premRNA is processed by capping splicing and polyadenylation 9 Describe the structure ofthe ribosome What are the A P and E sites 10 Describe the process oftranslation including initiation elongation and termination 11 What is an operon Describe the process of negative and positive regulation involving the lac repressor and catabolite activator protein CAP Section Two 1 Explain the Law of Segregation and the Law of Independent Assortment and how they are related to what happens during meiosis 2 What are the sum rule and the product rule When is each rule used What is the Chi square test and how is it used for 3 What is pedigree analysis What are the general features ofautosomal recessive disorders autosomal dominant disorders and Xlinked disorders in a pedigree 4 Distinguish between inheritance of the following incomplete dominance incomplete penetrance overdominance multiple alleles and codominance 5 Understand the inheritance of sex linked traits sex in uenced traits and sex limited traits Dr Julie StantonGeneral GeneticsFall 2010 6 What is epistasis How does the 97 ratio arise and why do we get this ratio What is complementation 7 Describe the concept of linkage How does linkage affect independent assortment How does crossing over affect linkage and independent assortment 8 Distinguish between the following terms parentals nonrecombinants nonparentals and recombinants 9 How do you calculate recombination frequency and map distance What are the proper units Understand how data from a dihybrid cross or a trihybrid cross can be used to make a genetic map 10 Describe cytoplasmic inheritance and maternal effect Section Three 1 Distinguish between conjugation transduction and transformation What is an F factor 2 Define the following terms metacentric submetacentric acrocentric and telocentric Describe a karyotype and the differences between p and q arms 3 Distinguish between the following chromosomal rearrangements deletions duplications inversions and translocations How might each one arise 4 What is euploidy What is aneuploidy Define the following triploidy polyploidy trisomy monosomy autopolyploidy and allopolyploidy 5 Define the following types of mutations transition transversion silent missense conservative missense nonconservative and nonsense 6 What is an insertion and what is a deletion Explain the difference between a frameshift mutation and an inframe mutation 7 Describe general mechanisms for base excision repair nucleotide excision repair and mismatch repair How are they similar and how are they different 8 Explain the two mechanisms for fixing a double strand break 9 Describe the double strand break model of homologous recombination and the Holliday model of homologous recombination How are they similar and how are they different 10 What are transposable elements and how were they discovered What effects can they have and what function might they have 11 Define the following population genetics population and gene pool How do you calculate allele and genotype frequencies Dr Julie StantonGeneral GeneticsFall 2010 12 What is the HardyWeinberg equation Why is it sometimes called the HardyWeinberg equilibrium What conditions must be met for a population to be in HardyWeinberg equilibrium 13 What is quantitative genetics Distinguish between continuous and discontinuous traits 14 What is polygenic inheritance How can the environment affect polygenic inheritance What is QTL mapping and how is it done Dr Julie StantonGeneral GeneticsFall 2010


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