DOSE OPTIMIZATION 1
DOSE OPTIMIZATION 1 PHA 5127
Popular in Course
Popular in Pharmaceutics
This 2 page Class Notes was uploaded by Judge Lebsack on Friday September 18, 2015. The Class Notes belongs to PHA 5127 at University of Florida taught by Staff in Fall. Since its upload, it has received 16 views. For similar materials see /class/206987/pha-5127-university-of-florida in Pharmaceutics at University of Florida.
Reviews for DOSE OPTIMIZATION 1
Report this Material
What is Karma?
Karma is the currency of StudySoup.
You can buy or earn more Karma at anytime and redeem it for class notes, study guides, flashcards, and more!
Date Created: 09/18/15
PHA 5127 Answers for Review 1 By Jeffrey Stark The following questions were written to test knowledge understanding and application of the concepts discussed thus far While working through these problems should aid in preparing for the exam do not assume that all material for the exam is covered here 1 A new IV preparation is reconstituted according to the manufacturers recommendations The appropriate volume is administered to a patient by IV bolus injection to provide a dose of 200 ug Blood samples were drawn just after the injection and four hours postinjection The plasma concentrations were 200 ugml and 100 ugml respectively Assume this drug follows a one compartment body model a Is this drug eliminated by a rst or zeroorder process What would the plasma concentration be eight hours after the injection in either case b Do you believe the correct dose was administered c What fraction of the dose administered should enter systemic circulation Given information Dose 200 ug by IV bolus Cpo 200 ugml Cp 100 ugml 4 hours a 1st or zero order 200 x 100 Cp X H glml I 0 4 thours There is no way to tell from the given information We do know that t12 4 hours since a four hour time period was required for the concentration to fall from 200 ugml to 100 ugml one half the initial value Without an additional conctime point we can not decide whether t12 is concentration dependent or not D Reviewsansreview1 doc I b lst order time hr Cpg gigml 0 200 gt 4 100 Zero order 0 20 2 4 100 s o gt c For an IV bolus dose all drug should enter systemic circulation since no absorption is required 2 A drug is administered by IV bolus injection to a patient After a dose of 500mg the initial plasma concentration was found to be 20 ugml After an oral formulation tablet was administered which provides the same dose an AUC of 100 ugmlhr was calculated from the analysis of plasma samples Assume that this drug follows a onecompartment body model with firstorder elimination and that the drug distributes evenly into all tissues The halflife of this drug is normally ten hours a What is the Vd for this drug in the patient b Compare the degree of plasma protein binding to tissue binding c If the free fraction in plasma increases how will the free fraction in tissues change d How long will it take for the plasma concentration to drop to 5ugml after the IV bolus dose is administered e What is the oral bioavailability of the tablet Given information IV dose 500 mg Cpo 20 ugml AUCoral 100 ugmlhr tlz 10 hours D Reviewsansreview1doc 2
Are you sure you want to buy this material for
You're already Subscribed!
Looks like you've already subscribed to StudySoup, you won't need to purchase another subscription to get this material. To access this material simply click 'View Full Document'