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Fundamental Genetics

by: Marlon Brown

Fundamental Genetics ZOL 341

Marlon Brown
GPA 3.78

Barbara Sears

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Barbara Sears
Class Notes
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This 3 page Class Notes was uploaded by Marlon Brown on Saturday September 19, 2015. The Class Notes belongs to ZOL 341 at Michigan State University taught by Barbara Sears in Fall. Since its upload, it has received 141 views. For similar materials see /class/207227/zol-341-michigan-state-university in Animal Science at Michigan State University.

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Date Created: 09/19/15
ZOL 341 Genetics Review Session Dec 11 2011 A Mutations and DNA Repair C 1 Which of the following amino acid replacements would be expected with the highest frequency among mutations induced by the thymine analog 5bromouracil n Met gt Leu Met gt Lys First base Leu gt Pro Pro gt Thr Thr gt Arg 2 Second base u c A G uuu Phe ucu UAU Tyr UGU cys uuc ucc Ser UAC UGC UUA Le UCA UAA Stop UGA Stop UUG UCG UAG Stop UGG Trp cuu ccu CAU His CGU cuc ccc CAC CGC Leu Pro Arg CUA CCA CAA GI CGA CUG CCG CAG CGG AUU Acu AAU A AGu S Auc lle Acc Thr AAc 5quot AGc er AUA ACA AAA L s AGA Ar AUG Met ACG AAG y AGG 9 Guu ch GAu As GGu GUC Gcc GAc P GGc Val Ala Gly GUA GCA GAA GI GGA GUG GCG GAG GGG reversion of his bacterial strains to his The portion of the his gene showing the mutations causing the his phenotype is shown below for three of the his tester strains Note only the sequence on the nontemplate strand is shown and the site of the mutation is indicated in each strain Wildtype 539 ATG GCA GCC TCA GGC ACC TCT GCT ACT TTC 339 Strain 1 539 ATG GCA GCC TCA GGC ACC TCT GCT ACT QTC 339 Strain 2 539 ATG GCA QCC TCA GGC ACC TCT GCT ACT TTC 339 Strain 3 539 ATG GCA GCC TCA GGC ACC TCG CTA CTT TCA 339 a What kind of mutation is found in each of the three his tester strains Be as specific as possible b On your own In the space provided below the DNA sequence for the wildtype and for strain 3 write the amino acid sequence encoded by the DNA sequence 0 Suppose you had his bacteria instead of his strains and assayed for mutagenesis to histidine auxotrophy How would the data that you could obtain from such a test be different from the information obtained by the Ames test Would it be more or less useful Would it be more or less efficient d Name one other feature of the Ames bacterial strains that contributes to the efficiency of this mutagenicity test QgtOC mgtnc mgtnc mgtnc In the Ames Test the carcinogenicity of chemicals is assessed by testing their ability to cause Third base B Medical amp population genetics Cystic fibrosis as an example of a human genetic disorder From the Cystic Fibrosis Foundation web site httpwwwcfforggreatstridescffactsheetl Cystic fibrosis CF is an inherited chronic disease that affects the lungs and digestive systems of about 30000 children and adults in the United States 70000 worldwide A defective gene causes the body to produce unusually thick sticky mucus that clogs the lungs and leads to lifethreatening lung infections and obstructs the pancreas and stops natural enzymes from helping the body break down and absorb food In the 1950s few children with cystic fibrosis lived to attend elementary school Today advances in research and medical treatments have further enhanced and extended life for children and adults with CF Many people with the disease can now expect to live into their 30s 40s and beyond 1 Cystic brosis is a genetic disease Pedigree 1 Pedigree 2 What type of inheritance is seen here Which individuals must have been carriers 2 Population amp transmission genetics of cystic brosis Suppose that 1 in 2500 people are afflicted with cystic fibrosis 1 Use this information to calculate allele frequencies 2 What is the frequency of carriers in this population 3 What is the chance that two carriers will mate and have an affected child 4 The relatively high frequency of heterozygotes in Northern European populations may be because they have increased resistance to bacterial infections of the exocrine system This frequency of the CF allele is much lower in Africans and Asians than in Caucasians What population genetics concepts help explain these observations


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