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by: Lindsey VonRueden MD

Pharmacokinetics PHAR 5332

Lindsey VonRueden MD
GPA 3.54


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Class Notes
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This 3 page Class Notes was uploaded by Lindsey VonRueden MD on Saturday September 19, 2015. The Class Notes belongs to PHAR 5332 at University of Houston taught by Staff in Fall. Since its upload, it has received 64 views. For similar materials see /class/208254/phar-5332-university-of-houston in Pharmacology at University of Houston.


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Date Created: 09/19/15
YEAR 2 SEMESTER PHARMACOKINETICS PHAR 5332 Course Description An introduction to the basic science principles of pharmacokinetics as they apply to drug absorption distribution metabolism and excretion Clinical science principles of pharmacokinetics will also be taught as they apply to the effect of disease on drug response including the influence of dose and dosage form on therapeutic and toxic response Cr 3 30 Prerequisite PHAR 4401 Cellular Life Sciences ll PHAR 4421 Organ Systems Life Sciences ll PHAR 4431 Pharmaceutics ll Course Pro ciencies The student will be able to Basic Pharmacokinetics 1 Describe basic pharmacokinetic terms and principles 2 Design experiments to answer a specific question and learn how to analyze data and evaluate literature reports with regard to drug disposition 3 Design an individualized drug dosing regimen to accomplish the intended therapeutic purpose 4 Explain and defend mathematical methods to write rate expressions and to form the integrated equations 5 Explain the purpose and limitations of mathematical and biological modeling and the use of models for describing drug disposition 6 Apply the concepts ofdifferent types of compartments to practical models 7 Plot blood drug concentrationtime and urinary excretiontime data in order to characterize the disposition ofthe drug being examined 8 Describe the meaning and implications of firstorder kinetics 9 Explain the meaning ofand be able to calculate pharmacokinetic parameters of elimination rate constant k elimination halflife t12 apparent volume of distributionV and areaunder the curve AUC for one compartment and multiple compartment models 10 Explain the limitations of the one compartment model and contrast it with multicompartmental models 11Explain the basic definitions of clearance and be able to calculate total body systemic clearance renal clearance and hepatic clearance 12 Explain the mechanisms of renal clearance and be able to relate the mechanism to the value of renal clearance 13 Describe extraction ratio and the differences between restrictive and nonrestrictive clearances 14 Explain the relationship between halflife and volume of distribution and clearance 15 Explain how rate of metabolism can influence drug disposition and response 16 Explain the differences between firstorder or linear or dose independent pharmacokinetics and saturable or dosedependent or capacitylimited pharmacokinetics and discuss the therapeutic and toxicological consequences 17 Describe how water is distributed throughout the body and the factors which affect drug distribution 18 Explain the importance of plasma protein binding ofdrugs and unbound drug concentration and how one determines binding and factors that affect binding 19 Discuss how a change in plasma protein binding will influence volume of distribution clearance elimination halflife steadystate unbound and total drug concentrations and the effect that will have on response 20 Plot data following a nonintravenous dose in order to determine the elimination halflife and absorption rate constant as well as elimination and absorption half lives 21 De ne and be able to calculate absolute and relative bioavailability 22 lnterpret modi ed bioavailabity based upon effects on biological physiological physiochemical and formulation factors on absorption kinetics 23 Explain the meaning of bioequivalence 24 Explain the implications of and be able to calculate the hepatic rstpass effect of drug metabolism and its effect on systemic drug concentration 25 Explain the meaning of accumulation and steadystate and the factors which influence steadystate plasma concentrations following constant rate intravenous infusion ofa drug or a multiple dosing regimen of intravenous bolus extra vascular dosing or intermitten intravenous infusion regimen 26 Design a continuous intravenous infusion regimen and a multiple dosing regimen to include a loading dose and an infusion dose or a maintenace dose 27 Explain how renal insufficiency may alter drug disposition and be able to design a dosing regimen appropriate for such a condition 28 Discuss the principles of dialysis including peritoneal hemodialysis and hemoperfusion 29 Predict ifdialysis will remove drug from the body and if so how to adjust a dosing regimen to account for drug removal 30 Predict the efficacy of dialysis for the treatment of drug overdose 31 Describe the relationship between drug response and plasma concentration 32 Explain how age may influence drug disposition and response and how to adjust a drug dosing regimen appropriately Clinical Pharmacokinetics 1 Identify pertinent pharmacokinetic parameters for each drug studied during the course to design dosing regimens or predict concentrations from administered regimens 01h A l O l G Discuss general variability of drug concentration measurements caused by assay techniques collection techniques and dose administration techniques Discuss and evaluate the effects of variability genetics age weight disease and interacting drugs on the pharmacokinetics of reviewed drugs Describe methods to evaluate the benefits oftherapeutic drug monitoring Discuss the effects ofdialysis volume of distribution metabolite formation and pharmacological response on drug pharmacokinetics and patient response Given cases presented by the instructors the student will be able to identify which patients present potential dosage problems a outline an approach for solving a patient39s dosageregimen problems b construct an appropriate pharmacokinetic model to apply to the patient and drug develop a blood sampling plan for each patient predict or determine a drug39s clearance halflife and volume of distribution in example patients identify pertinent variables necessary to design a dosing regimen These include bioavailability F ofthe dosage form chosen the fraction of dose that is parent drug ie the salt the best patient weight to use in clearance or volume predictions ie actual ideal or some adjusted weight use the literature andor a patient39s data to design a pragmatic dosage regimen for the patient g formulate the appropriate times for followup ofthe drug39s blood concentration and therapeutic response of the patient 00 39D n Compare and contrast the potential effects of pharmacokinetic monitoring on the care ofa patient Students should substantiate their evaluation with logical data Utilize computer software to analyze patient data and construct dosage regimens


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