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Organ Systems Life Sciences II

by: Lindsey VonRueden MD

Organ Systems Life Sciences II PHAR 4421

Marketplace > University of Houston > Pharmacology > PHAR 4421 > Organ Systems Life Sciences II
Lindsey VonRueden MD
GPA 3.54


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Class Notes
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This 4 page Class Notes was uploaded by Lindsey VonRueden MD on Saturday September 19, 2015. The Class Notes belongs to PHAR 4421 at University of Houston taught by Staff in Fall. Since its upload, it has received 82 views. For similar materials see /class/208256/phar-4421-university-of-houston in Pharmacology at University of Houston.

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Date Created: 09/19/15
YEAR SEMESTER ORGAN SYSTEMS LIFE SCIENCES II PHAR 4421 Course Description Principles of human anatomy physiology and pathophysiology of cardiovascular respiratory renal gastrointestinal reproductive and endocrine systems with emphasis on those systems and disease states commonly encountered in the provision of pharmaceutical care Cr 4 40 Prerequisite PHAR 4320 Organ Systems Life Sciences Course Pro ciencies The student will be able to Demonstrate an understanding of mammalian physiology pathophysiology and anatomy in the fetal state adult state and aged state where applicable Describe constituents ofthe blood including the formed elements and the roles of the plasma proteins Explain the origin and production of blood cells and factors regulating their production Describe the normal values for each type of blood cell and their function and fate Discuss the synthesis composition function and disposition of hemoglobin Describe the causes and consequences arising from blood cell disorders Describe the mechanisms of hemostasis factors that participate in blood coagulation signi cance of platelets hemolysis thromboembolism hemophilia and thrombocytopenia Explain blood types agglutination ABO groups Rhfactors erythroblastosis fetalis and its prevention Describe the anatomy the circulation and distribution of blood through various organs 10 Describe the basics of hemodynamics and factors affecting blood flow 11Compare and contrast the anatomical characteristics of arteries and veins and the significance of resistant versus compliant vessels 12 Describe the characteristics of capillaries and factors affecting microcirculation and the exchange of substances and fluid between capillaries and interstitial spaces and origins of lymph factors that can promote edema and the significance of plasma colloidal osmotic pressure 13 Describe the function of the venous system venous valves and the cause and consequences of varicose veins and the factors that can modulate venous return to the heart 14 Describe the various phases of the cardiac cycle anatomy and function of cardiac valves relationship between inotropic and chronotropic properties and cardiac output and priciples ofelectrophysiology ofthe heart JON ICDU39I A G O 15 Discuss the regulation of cardiac output Starlings Law of Heart in uence of pre load and after load and neural regulation of cardiac output and arterial blood pressure Describe environmental in uence including space on cardiovascular function 16 Describe heart failure systolic and diastolic dysfunctions compensated and decompensated states causes of systemic and pulmonary edema 17 Describe the etiology of primary and secondary hypertension and consequences of untreated hypertension 18 Describe the anatomy of the respiratory system including the respiratory membrane and discuss the physics and physiology of respiration 19 De ne pulmonary pressures volumes and capacities and list the normal values for each 20 Discuss the significance of surfactant in alveoli and hyaline membrane disease 21 Describe compliance of the lungs and its significance in impact on gaseous exchange affecting pulmonary volumes and capacitance 22 Describe factors determining the diffusion of gases in the lungs including partial pressures and values concentration of gases diffusion capacities and values 23 Discuss the transport of gases in the blood This includes values and the role of hemoglobin tissues maximum saturations arterial and venous differences carbon monoxide poisoning and signifance of carbon dioxide production and disposition 24 Discuss central nervous system mechanisms and chemoreceptors in the regulation of respiration 25 Discuss the symptoms and mechanisms underlying respiratory disorders emphysema chronic bronchitis pneumonia asthma tuberculosis hyaline membrane disease 26 Describe the gross anatomy and function ofthe kidney and autoregulation of renal blood flow 27 Describe the anatomy of the nephron macula densa and juxtaglomerular apparatus 28 Describe the physiology of urine production mechanisms of glomerular filtration GFR factors affecting GFR and the signi cance of inulin or creatinine clearance in estimating GFR 29 Discuss the mechanisms of reabsorption and secretion of ions solutes and water in different segments of nephrons and the significance of chloride transport in the loop of Henle 30 Discuss the concept of plasma clearance and methods of measuring and calculating plasma clearance 31 Describe counter current extraction mechanisms and their significance in the regulation of urine concentration and the role of osmoreceptors and antidiuretic hormones 32 Describe factors which contribute participate in electrolyte and extracellular fluid homeostasis eg angiotensin II aldosterone antidiuretic hormone atrial natriuretic peptides natriuretic hormone andor neural mechanism 33 Discuss causes symptoms and consequences of renal pathology eg acute renal failure as caused by drugs and disease chronic renal failure as caused by drugs and diseases including hypertensive kidney disease and diabetic nephropathy nephrotic syndrome and tubular disorders 34 Discuss regulation of acidbase balance endogenous buffer systems roles of respiratory and renal systems and distinguish between metabolic and respiratory acidosis or alkalosis and compensatory mechanisms 35 Identify the major hormonal secretions and cite the primary functions ofthe major endocrine glandsincluding the hypothalamus pituitary pancreatic islets thyroid parathyroids adrenals ovaries and testes 36 Describe the biosynthesis control of secretion and major target organs of the following hormones insulin glucagon thyroxine parathyroid hormone calcitonin hypothalamic hormones anterior and posterior pituitary hormones cortisol and aldosterone 37 Discuss the etiologies pathophysiologies and clinical characteristics of the major endocrine disorders including diabetes mellitus hypothyroidism hyperthyroidism Graves disease osteoporosis hyperprolactinemia Cushing s syndrome and adrenal insufficiency states 38 Identify the anatomical and physiological aspects of sexual differentiation including the factors involved in gender determination 39 Describe the agerelated changes in reproductive function including pubertal changes and senescence climacteric in relation to hormonal changes ofthe hypothalamicpituitarygonadal axis 40 Describe male reproductive function including the synthesis and secretion of androgens physiological actions ofandrogens and the process of spermatogenesis 41 Discuss female reproductive function including the ovarian cycle oogenesis hormonal patterns of the menstrual cycle and associated changes in the female reproductive tract 42 Describe the processes of fertilization and implantation nidation maternal hormonal changes and the functions of the placenta in human pregnancy 43 Outline the general organizational structure of layers of the gastrointestinal tract identify the autonomic and enteric neural components that supply the tract 44 Identify the anatomical regions of the gastrointestinal tract and cite the functions ofthese regions 45 Describe the types of gastrointestinal motility and the regulation of motility by hormonal and neural systems 46 Identify the specific sources content regulation and functions of gastrointestinal secretions 47 Outline the processes involved in the digestion and gastrointestinal absorption of dietary carbohydrates proteins and lipids indicate the sites and mechanisms involved in the gastrointestinal absorption of electrolytes 48 Discuss the functions and list the secretions ofthe exocrine pancreas the liver and the gall bladder 49 Describe the etiologies pathophysiologies and clinical characteristics of major disorders of the gastrointestinal tract including peptic ulcer gastritis GERD ulcerative colitis Crohn s disease pancreatitis hepatitis and symptoms such as diarrhea and constipation


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