General Biochemistry I
General Biochemistry I BCHS 3304
Popular in Course
Popular in Biochemistry and Molecular Biology
This 5 page Class Notes was uploaded by Elody Boehm on Saturday September 19, 2015. The Class Notes belongs to BCHS 3304 at University of Houston taught by Glen Legge in Fall. Since its upload, it has received 18 views. For similar materials see /class/208348/bchs-3304-university-of-houston in Biochemistry and Molecular Biology at University of Houston.
Reviews for General Biochemistry I
Report this Material
What is Karma?
Karma is the currency of StudySoup.
You can buy or earn more Karma at anytime and redeem it for class notes, study guides, flashcards, and more!
Date Created: 09/19/15
University ofHouston BCHS SEEM 3de Biochemistry l 7 Fall ZEUS S ectinn 127 TuesdayThursday 113l AM 7 1 PM l Z SW Instructor Dr GlenB Le e Phone 7137743783 Office HSC 4BR Email gleggeuhedu Of ce hours Tuesday and Thursday 1 IUVZ an FM urby appuimmeht Course web page httpwww chsuheawgieggmmhiug The lecture notes and homework will be posted on the Web httpwwwbchsedugleggeteaching These notes are he a substitute for eiass pameipaueh These notes are posted unthe weh althuugh they may he tered before eiass They are intended u make you pay auehueh in eiass so take these notes wuh you Dun39tjust sum eiass andjust upy hmesu Read the assigned material before the lecture Collect Homework 1 and START 1T e at the Molecular Level Biochemistry is the study ofbiological at a chemical level ruimuuumu of mummism nuyim39 us lik LliuiiiK li is Hm mu m m ulieiiiiAw Mus Biochemistry is hi uiuuusuuiuun s mice eveiiiupuig mm illeuils re mlug plenum uuumlmlngy uiicivbmluu phiinuncnlo 1 hudyiiyueieh huu Mimi amvumum i Vlim Medic Elvemiml and tlirerzhmeimmml mums M limhgiml inoleullnquot 2 Him 4h 1min n F iletlile ui39emci um carli mlieiquot 3 now due me ecu Snitlh sizc um ileum blOlOZ iclll ilialccules l How 13 may eouwml and used bv me cell39 lt mm m the umimiusms I mymwiim bioimehi iiialmulm and the morehinlmg m Ilitiracm illcs i ml i m i l Introduction to the Chemistry of Life E ORlGlN OF LlFE Universe is lSVZEI lZIllllEIn years old rBlG BANG imuaiiy ii2 was made then cundensedtu iie Overthe hiihehs ufyears undenhehgu eehuiuehs complex molecules formed Cumplicated ehemieai reactions started eeeumhg e intermolecular interactions and carbon based chemistry developed Frum this milieu sprang the prupei ty er LIFE Pruhiuiii Winkl LlHHunthlu u Mul i iimllmimlt ulwhummhw hilvlrlrl m r umuhuuurmummi limLiiuivuhmli39 Wm esiw Vliu39 an i U Nro ygx39nlul um 39 mum luv 7 5 on Phusnhmnus m e gt weigh i m sumu rs i UquotuLllomuL39lW 4 7quotquot ram minimum ns 4 mn a r 4 S Mo 5quot Mw ungumsuu me cu 70quot mm uniwhen whim sum 39lJiiiu lDii iminszlin Hiuihuuw Mihiiihuuum Miwiuum The Physical Laws of Life philosophers thought life contained a vital force or vitalism but this has been rejected by modem science Haldane 7 simple organic compounds lrom H10 N2 02 Urey 7 chemical synthesis olurea Living organisms operate within the same physical laws that apply to physics and chemlstry IConserva on olMass Energy Laws or Thermodynamics 39Principles of Chemical Reactions Molecular Logic of Life These physical laws describe several axioms that make up the MolecularLogic ofLife These axioms de ne Energy converted to work Catalytic chemical transformations Assembly ofmolecules with great complexity from simple I S 39 wiiipuiieiit organelles andflnally assemble into acell Store andpass on instructions for the assembly ofall future generations from simple nonliving precursors Life is in constant flux Enzyme catalyzed reactions Substrate g s 2 Products 10393 sec milli sec Unwinding ofDNA 1039 c sec mlcro se 1039 1039 1095 1085 1055 1039 10 s 1035 femto i pico 7 nano i micrr milli sec femto fs excitation of chlorophyll pico ps charge separation in photosynthesis nano ns hinge ote39 acti I10 810 ns uorescence lifetime mlcro us A u w n milli rns enzymatic reactions generation ofbacteria 2 3 x 109 sec average human life span What distinguishes living organis 1 structurally complicated and highly organized a 39 tli 39 ernal structures b many kinds of complicated molecules proteins DNA RNA starches and lipids etc inanimate objects sand clay are mixtures ofsimple compounds 2 Living organisms a extract b tmnsform ENERGY c store d use Living things can extract energy from the environment Chemical chemoaiitotrophs or lithoautotrophs HIS gt 2H si 2e39 2NH3 40 gt 2HNO 2H20 4Fec03 02 GHZO gt 4Fe0H3 4c02 0139 Sunlight Photoautotrophs nco2 nHZO hugt CHZO no2 Energy is needed to build and maintain structures a mechanical energy muscles b chemical energy electric eel osmotic energy plant turger c d light energy bioluminescence 3 Most characteristic attribute of living things is self replication and self assembly it is the quintessence of the living state 1 single bacteria gt 109 in 24 hr With nearpa fect delity during replication A rrv ml 5quot onuil rium grow L quotquot quot39L 39 39 death Life is a set of relationships characterizing the nature function and intaaction of biomolecules The Essential Role of Water HZO is the key to understanding the behavior of macromolecules It is the solvent of life and all living transformations occur in an aqueous media Life is thought to have arisen from the sea Even waterinsoluble compounds such as lipid membranes derive their nature and function by their interactions with HZO Condensation reactions IChemic o al Evolutions simple molecules condmse to form more complex rms polymas ll R 0H 1 39 R39 Ii Connoralum Hyrlinlyena 104 up R C 39H R Replication through complementarity Specific pairing of functional groups gives rise h CLD L so to Cm npla nentarlty ore complex molecules s increases cha39nical u x i l versatility l 1L i Ll Compla39nentarlty makes it whim 39 K possible for macromolecules to replicate r Ovatime natural selection 3 a lm 39 9 I y quot1 a Y 6mm a j favored molecules that I l if i gt made accurate copies of quot5quot 39 391 W themselves 39 iiu New Ammo otll HlUUE3 Lcuclw Nuclcnlnus s A warm a lluclcl mi s A WSMLI mum i 5m msde How did organisms evolve Blind mtclimaker principle small mutations arise at ran 0m 1 Evolution is not directed 2 Evolution requires builtin sloppiness 3 Evolution is constrained by the past 4 Evolution is ongoing Cell gt multi cell varied and diverse and evolutionary processes lead to diversity but life has many common themes and processes Organic compounds fuund in hvmg urgamsms are apruduet uf Blulugcal Actimty Eiomolecules are selected by evolution the lit are kept the not lit are discarded The mure t remain and cununue tu evulve The Evolution of Cells provided the Advantage of COM ARTNIENTATION gt mm is its m commands memoir in genes is Mvmullnnmu piloan l39nllulnrArminlure Vanda mummieil met me Ihmlglu m as ilie precllnnr to cell Tim nininasuvauld lime lull llm nluluy tn ducld cher 6 clienucnl reachmls mnl mmva maeunne 50 mm QIhywue nlnce a slielleied eiunnumeut minim iliem a campenm39i ill m uceu n mllerl mum unneiuuimi 11m eoulunnuisul men has the owomlluu39m mulis nl39alvc ui anler m eulmuce in ndvmunae 7 mm W uni immune mman unis mintil niuum cell cumulus in many ns mama hfrelenl was nf molmulcs A Common taslenum L roll conlnms millions aluiulerules mpksculm suuursouu rummu compounds wv I l quotMumm xu Ingram 1m PM u Mm Phylugeneu Tree ufShuwmg Three dumams ufOrgamsms H unAunu u 39u u H m uW Hquot u Wm WmI e u mm m m w v w w mm m 4 mm H 4 mn WWWW Wt r m mumv 1w WWW m m numwuw memvhuHunHlvmmmI mum enw y u mt Lect Thursd Units and Th ermodynami cs ay 82808
Are you sure you want to buy this material for
You're already Subscribed!
Looks like you've already subscribed to StudySoup, you won't need to purchase another subscription to get this material. To access this material simply click 'View Full Document'