New User Special Price Expires in

Let's log you in.

Sign in with Facebook


Don't have a StudySoup account? Create one here!


Create a StudySoup account

Be part of our community, it's free to join!

Sign up with Facebook


Create your account
By creating an account you agree to StudySoup's terms and conditions and privacy policy

Already have a StudySoup account? Login here


by: Maymie Gaylord


Maymie Gaylord
GPA 3.52

Paul Katz

Almost Ready


These notes were just uploaded, and will be ready to view shortly.

Purchase these notes here, or revisit this page.

Either way, we'll remind you when they're ready :)

Preview These Notes for FREE

Get a free preview of these Notes, just enter your email below.

Unlock Preview
Unlock Preview

Preview these materials now for free

Why put in your email? Get access to more of this material and other relevant free materials for your school

View Preview

About this Document

Paul Katz
Class Notes
25 ?




Popular in Course

Popular in Biology

This 2 page Class Notes was uploaded by Maymie Gaylord on Monday September 21, 2015. The Class Notes belongs to BIOL 6102 at Georgia State University taught by Paul Katz in Fall. Since its upload, it has received 18 views. For similar materials see /class/209916/biol-6102-georgia-state-university in Biology at Georgia State University.




Report this Material


What is Karma?


Karma is the currency of StudySoup.

You can buy or earn more Karma at anytime and redeem it for class notes, study guides, flashcards, and more!

Date Created: 09/21/15
July 16 2010 Biol 6102 Neurobiology Electrical Signaling Membrane Potential Chapter 3 Membrane Potential 0 Basis of cellular signaling Action Potential Synaptic Potential Terminology 0 Charge positive or negative and carried by ions units Coulom s 0 Voltage Potential a measure of how much charge is separated units Volts V Current I the flow of positive charge units Amperes Permeability the relative ease with which ions can flow through channels 0 Conductance G a measure ofthe ease with which charge can flow units Siemens S inverse of Resistance R units Ohms Q Method for recording Neuronal Membrane Potential Voltage Recording with intracellular microelectrodes records the potential difference across the membrane Physical basis for membrane potential 0 Separation of charge by the membrane 0 Differential concentrations of ions across membrane NaK pump maintains distribution 0 Selective Permeability to Na K Cl39 ions esting conductance Based on ion channels Nernst Equilibrium Potential 0 This is very importantlll The Equilibrium potential for an ion is the potential at which there is no net movement of an ion due to a balance between electrical and chemical O O gradients Rim X19 X ZF XL 0 Where EX Equilibrium Potential for ion X Xo is the concentration of ion X outside the neuron Xi is the concentration of ion X inside the neuron R Universal gas constant T Temperature in Kelvin Z Valence F Faraday constant Simplified Nernst Equation At 37 C RTF267mV The conversion of natural logarithm to base 10 logarithm is 23 E Q Io u x 2 g Xi Glial cells are very permeable to K but not permeable to other ions Therefore glial membrane potential is the same as EK o Vmem is determined by the ratio of Ko Ki p1 lf potential is across membrane is different than EX then a current will flow 0 Ix Gx vm Ex This isjust a variation of Ohm s law VR Ix is the current carried by the ion G is conductance to the ion Vm Ex is the driving force on the ion Neurons are permeable to more than just K so it is more complicated to determine their resting potentials based on ion concentrations Very Permeable to K Only slightly permeable to Na Influx of Na balanced by efflux of K Results in a resting potential slightly depolarized from EK Goldman Equation for predicting the membrane potential of a neuron v 62 log PKKo PNaNao PCI Cli PKKi PNaNai PCICIo Where V the membrane potential PX the permeability to ion X 0 At rest this approaches Nernst Equilibrium potential for K herefore membrane potential depolarizes if extracellular K is raised 0 At peak of action potential this approaches Nernst Equilibrium potential for Na Due to high permeability for sodium 0000 Ion Channels General Properties 0 Membrane spanning proteins Comprised of subunits or pseudosubunits hydrophobic amino acids 0 Ion selective due to properties ofthe pore region hydrophilic amino acids Neurons have an Ion Transporter Pump to redistribute Na and K Prevents the ionic gradients from dissipating o Requires ATP 0 Extrudes 3 Na for every 2 K it brings in p2


Buy Material

Are you sure you want to buy this material for

25 Karma

Buy Material

BOOM! Enjoy Your Free Notes!

We've added these Notes to your profile, click here to view them now.


You're already Subscribed!

Looks like you've already subscribed to StudySoup, you won't need to purchase another subscription to get this material. To access this material simply click 'View Full Document'

Why people love StudySoup

Bentley McCaw University of Florida

"I was shooting for a perfect 4.0 GPA this semester. Having StudySoup as a study aid was critical to helping me achieve my goal...and I nailed it!"

Amaris Trozzo George Washington University

"I made $350 in just two days after posting my first study guide."

Steve Martinelli UC Los Angeles

"There's no way I would have passed my Organic Chemistry class this semester without the notes and study guides I got from StudySoup."

Parker Thompson 500 Startups

"It's a great way for students to improve their educational experience and it seemed like a product that everybody wants, so all the people participating are winning."

Become an Elite Notetaker and start selling your notes online!

Refund Policy


All subscriptions to StudySoup are paid in full at the time of subscribing. To change your credit card information or to cancel your subscription, go to "Edit Settings". All credit card information will be available there. If you should decide to cancel your subscription, it will continue to be valid until the next payment period, as all payments for the current period were made in advance. For special circumstances, please email


StudySoup has more than 1 million course-specific study resources to help students study smarter. If you’re having trouble finding what you’re looking for, our customer support team can help you find what you need! Feel free to contact them here:

Recurring Subscriptions: If you have canceled your recurring subscription on the day of renewal and have not downloaded any documents, you may request a refund by submitting an email to

Satisfaction Guarantee: If you’re not satisfied with your subscription, you can contact us for further help. Contact must be made within 3 business days of your subscription purchase and your refund request will be subject for review.

Please Note: Refunds can never be provided more than 30 days after the initial purchase date regardless of your activity on the site.