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Principles of Animal Cellular and Developmental Biology

by: Aryanna Dooley

Principles of Animal Cellular and Developmental Biology EEOB 415

Marketplace > Ohio State University > Ecology, Evolution, and Marine Biology > EEOB 415 > Principles of Animal Cellular and Developmental Biology
Aryanna Dooley
GPA 3.98

Cynthia Bronson

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Cynthia Bronson
Class Notes
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This 2 page Class Notes was uploaded by Aryanna Dooley on Monday September 21, 2015. The Class Notes belongs to EEOB 415 at Ohio State University taught by Cynthia Bronson in Fall. Since its upload, it has received 47 views. For similar materials see /class/209992/eeob-415-ohio-state-university in Ecology, Evolution, and Marine Biology at Ohio State University.

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Date Created: 09/21/15
21412 7 Lecture 12 Extracellular Matrix EC 3 1 Secreted by cells Proteins bers Polysaccharides ground substance Functions Structural support Orienting cells Physical structure Fill space Form gels Regulate molecular traf c Chemical signaling Bind growth factors Crosslink membrane proteins Regulate secreted proteins Immobilize store insulate inactive Ex In ammation 7 lot of signals and most are regulatedadjusted by ECM Dominates connective tissue eg blood bone fat Most common in 4 quot 39 matrix connective cell broblast Locally produce matrix Cytoskeleton aligns with ECM bers Examples Chondroblast forms cartilage Holds water Comperssible Resilient Avascularized Osteoblast forms bone Mineral precipitation Highly vascularized Protein bers Collagen Major protein highly abundant Structure Triplestranded helix Each strand bril 20 types based on 25 brils Very rigid and stable ropelike Orientation guided by Fibroblasts Cosecreted matrix molecules F ibrilforming cables Fibrilassociated link brils and ECM Elastin Allows tissues to stretch and recoil rubberbandlike Usually mixed with collagen Fibronectin Attaches cells to matrix Plasma fibronectin 7 soluble form Fibronectin brils 7 between cell surface and ECM Sequence recognized by integrins Laminin Helps form basal lamina Mainly under epithelium muscle fat Regulate cell migration and orientation Others organizing Integrin Type IV collagen Perlecan Nidogen 39 idcx g1 39 39 ycaus GAGs Traits Long sugar chains Repeating disaccharides Lots of negative charge Extremely hydrophilic Attract water Take up space Turgid Hyaluronan Simplest glycosaminoglycan Little branching few protein links Prevalent during early development Readily lls space but resists compression Proteoglycans GAGs covalently linked to protein eg aggrecan Functions Support Filtering Growth factor signaling Regulate secreted protein activity


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