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This 3 page Class Notes was uploaded by AnnaClippinger on Tuesday September 22, 2015. The Class Notes belongs to BIOL-L211 2521 at Indiana University taught by Megan Dunn in Summer 2015. Since its upload, it has received 35 views. For similar materials see Molecular Biology in Biology at Indiana University.
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Date Created: 09/22/15
L C iU it 1 l What is molecular biology iihe study of biologyquot at the molecular level the obvious de nition Erom dictionarycom quotThe loranch of loiologwrr that deals with the nature of biological phenomena at the molecular level through the study of DNA and RNA proteins and other macromolecules involved in genetic information and cell function characteristically making use of advanced tools and techniques of separation manipulation imaging and analysis In other words the study of the structure and function of macromolecules NULIGI39C Acid 39PV 39ins 39 UPIquot E pom sacs ha Haas 11 fquot THC birth quot ol mru39lelwr Bro WM quotMolecular Biology of the Gene the 3951 swucfuw 6 DNA was OHS J Watson and Crick with some help discovered the structure of DNA is a double helix quotIt has not escaped our notice that the speci c pairing we have postulated irnirrrediateirlr suggests a possibie copying mechanism for the genetic material Watson and Crick Nature 1953 a How DNA canoe molt calm Em memem S Funalwmcn rwls MOWUIW bro 9639 Drawing ofthe DNA double helix by Francis Cricik 1953i 12 The central dogma The central dogma explains the directional flow of genetic information in a cell 9 M1 EllilainM39l lan M39 howj our E GEE on Protein Synthesis inst 195 Proposed in Francis Crick i956 The Doctrine of the Triad E ha Cantrell Dogma quotDnee infermtion him get into a pretein 11 can39t get out again Intonation here manna the anemone of the amino acid residues at other sequeneee relateti to it End Point PROTgi N m RM 1 Hfa 39 A vb5 e Pmtun 39 but never I Q M W Freight QJXMm w w g Q in simpler terms DNA A RNA protein A DNA U i mnsmm RNA mum t men Taml mm W 13 httpjforo lesnlrnmnihgow39gpsfretrle uefFiesourceMletadataSCElEFF Why study molecular biology It s required For your major lFor medical school graduate school etci llt intersects with other courses Genetics Biochemistry Cell biology 9 Chemistry Many others It39s essential for understanding more complex biologicai concepts It39s relevant It s newsworthy 14 l l Emma w predict tm own Scraman at Cl Molecular Biology in the News l W U UINWW WW twill5W W be t39flll l ill tatat DNA iemtnm on own Weitent who W thnn quotNew Life for Ancient DNA Scienti c American August 2012 What we understand about extinct creatures largely comes from fossils or preserved carcass s we rcmd rule N owlHm fossn race 40000 year old baby woolly mammoth found in Siberian permafrost A 1 DP woolly mmmm CWFC MSEJ Artist s rendition of woolly mammoths Can learn about physical characteristics But what about cellular processes For emes la owdl d they wallow focal httpflwwwttelegraphconuklsciencez sciencenewsl ZElzZ f39eahwwoolly mammo t gehtm 15 httpzjlwwwphotouklnaturellifeWoolILrnamrnoth Molecular Biology in the News A 50 00 r ppm 3 1w dFro39mn 9 a Wan zv aw arm hhe39 mbgm LI this gun A ma a 393 Hemoglobin a protein bin 5 oxygen m cm glam a r 1mm lungquot WEEHMWCJ 9 the lungs and delivers it to tissues C ld laemps In tissue cells a H I At low temperatures hemoglobin has dif culty releasing oxygen llen tnglnl iin 7 molecules A potential problem in the extremities of arctic animal39sl Oxygen hundred with hul39t loglnhin molecules Woolly mammoths Arctic are evolutionarily related to Asian and African elephants warmer climates vaotheslS MommaM homo Gldoflfl evolved 0 lmprow mom in Gold MPmrmres Hypothesis was experimentally tested with data presented in a primary source httpjfwwwwebmdcomla tot guideslhemoglobin WWW1139 40 mamal toll
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