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This 19 page Class Notes was uploaded by Hailie Turcotte on Saturday September 26, 2015. The Class Notes belongs to BIO E 302 at Clemson University taught by Staff in Fall. Since its upload, it has received 32 views. For similar materials see /class/214255/bio-e-302-clemson-university in Bioengineering at Clemson University.
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Date Created: 09/26/15
Biomaterials BIOE 302 Spring 2012 Alexey Vertegel PhD Associate Professor Department of Bioengineering Course Overview Instructor Alexey Vertegel PhD Associate Professor of Bioengineering Office 202 Rhodes Annex Phone 6560801 Email verteqeclemsonedu Office Hours Monday 1303 pm Friday 1303 pm Prereguisites CH 201 CME 210 or instructor consent what you actually need is general understanding of basic concepts of Physics Chemistry and Biochemistry Course Overview Recommended Textbooks An Introduction to TissueBiomaterial Interactions Kay C Dee David A Puleo and Rena Bizios John VWey and Sons ISBN 0471253944 2002 Biomaterials Science Second Edition Buddy Ratner Alan Hoffman Frederick Schoen Jack Lemons Academic Press ISBN 9780125824637 2004 Note An older edition is available onine from campus free through wwwclemsonedulibrarv Course Overview lclickers required 1 lclickers can be purchased at CCIT Support Center located beneath Harcombe Dining Hall 2 lfyou already have an lclicker you can use it 3 lclickers WILL NOT be used for grading 4 More info at httpwwwiclickercom Course Overview What this course is about Biomaterials are materials that are used in contactwith biological systems This course is about interactions of materials with biological systems at different scale levels from biomolecules to entire organs and implications of these interactions on both material and biological function Structure of the course Part 1 Fundamentals classes of biomaterials overview of biomolecules themodynamics of surfacebiomolecule interactions Part 2 Concepts Molecular basis of cell and tissuebiomaterial interactions Part 3 Implications how to fine tune material properties to achieve desirable performance Part 4 Applications Examples of biomaterials designed for specific biomedical applications Course Overview Grading approximate Homework 15 Lab 25 Quizzes 10 Midterm exam 20 Final exam 30 You will need to understand basic concepts and be able to apply them Do not worry about grammar errors Occasional calculation errors will also be forgiven Work in class is appreciated Questions comments and active participation in discussions is encouraged and rewarded Course Overview Quizzes A7 min quiz will be given at the end of each lecture It will test a concept discussed in the lecture You can get maximum 1 points for each quiz 05 points are given to anyone who attempts the quiz and maximum 05 points is given for correct answer If you miss a lecture you can make up the quiz but you will lose 05 attendance points Bring calculators Attendance Policy The class meets TTH at 1230 in 111 Rhodes Annex and TVVTH at 2 pm in 315 Rhodes Annex Students are expected to attend all lectures If no prior arrangements have been made students are authorized to leave fifteen minutes after beginning of the lecture if instructor does not show up Use of laptop computers is not allowed during the class Ictureisunrelatedmnm Labs Lab Schedule tentative 4 graded experiments surgery lab optional Lab 100 Introduction to courses lab demo Laboratory Skills Pippetting Excel Data plots statistics literature search Lab 101 Abstract Basics and Presentation Skills A Materials Testing I 3 Point Bend Test B Materials Testing H Contact Angle C Protein Adsorption Homework and Exams Homeworks 35 assignments ranging from 3 to 9 points Exams Consist of problemsolving questions Each problem starts with a description of a clinical or business situation relevant to the use of a certain biomaterial The vignette provides both relevant and irrelevant information about the case much like what you will encounter in real life Several questions that test your understanding of basic concepts and ability to apply them to a real life situation will follow Deadlines for homeworks and dates for midterm and final exams CANNOT be changed A documented medical condition of yourself or a close relative may be accepted as the excuse at the discretion of the instructor Late turn ins for homeworks may be accepted with 25 same day turnins only or 50 penalty at the discretion of the instructor Grading policy A gt 90 B gt75 C gt66 D gt50 F lt50 Course Overview Disability access It is University policy to provide on a flexible and individual basis reasonable accommodations to students who have disabilities Students are encouraged to contact Student Disability Services to discuss their individual needs for accommodation Honor Code Policy The college of engineering has an Honor Code A copy of the Honor Code is available at httpwwwcescemsonedustudent infohonor codehtm What are biomaterials A nonviable material used in a medical device intended to interact with biological systems Ratner MEDICAL DEVICE EXAMPLES US Sutures temporary or bioresorbable 250 M Catheters uid transport tubes 200 M Blood Bags 40 M Contact Lenses 30 M hrtraocular Lenses 25 M Knee and Hip Prostheses 05 M Breast Prostheses cancer or cosmetic 025 M Dental Implants 09 M Renal Dialyzers patients 03 M OxygenatorsCPB S cardiopuhnonary bypass system 03 M facilitates open heart surgery Vascular Grafts 03 M Pacemakers pulse generators 04 M Biomaterials cover all classes of materials Eu HA A1103 TL sihcuue Cranial 316T 55 TL anyhc HA TC P Mamllofacml reconsmcuon A1 TC ILAJPLA Biogizss Ti T Dental acaylic gold 316L SS C0 Cx39MD Ti TiA1 V A1101 11k Bioglass Degradable Sutures copalymers of FLA PGA PCL PTMC PDO Hean C oCr Mo TLAI li puoly c C ePTFE PET PL R Pacemaker 316L SS Pt FUR silicone PET Spinal C oCrMq Ti HA UHLIWPE I 1 Loadrbeaiiug Onharpeclic 911103 Ziu39couia 3161 SS TL Ti AlV C39oCfMo me PE Pros letic joints 316 SS CoCr Mo Ti TLAl V39 silicone meTE acrylic Tendon amp Ligament PLAWC FLA Polylactide ber EPTFE PET LHNTE PGA polyglycnlide PTMCpolyn39imethylenecaxbouate PDOpolyp dinxanone FUR polyurethane eP39I39FE expanded polyteua uomethyleue L39HIViWPE ulu alngll mall I polye lylene PETpolyethyleme ta ephthalate HA hydroxyapatire SS stainless steel Bone Fixation 316 SS CoCrMn TL quotIiAHquotr FLAHA PL L PGA Structural Hierarchies Biomaterials Engineering spans 8 orders of magnitude in structure Svnthetic Materials Living Organisms Chemical Primary Structure 1040111 Molecules H30 peptides salts i f Higher Order Structure The realm of Organelles lysosomes nucleus 111itoc110ndria biomaterials engineering lvlicrostiuc rure r C ells V Cmnposites 10quot 111 Tissues Parts Organs Devices Individuals Bulk vs surface Bulk properties of biomaterial determine its function Surface properties of biomaterial determine its interactions with the body Eg vascular graft lclickers Which of the following is a bulk property of a material A Particle size B Specific surface area C Electrical conductivity D Chemical composition E The Avogadro s number lclickers Which of the following is a surface property of a material A Young s modulus B Roughness C Density D Gibbs free energy E Surface tension Quiz 1 In the list below mark bulk B and surface S properties Density Weight Specific surface area Meting point Roughness Coor 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