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Human Drug Use

by: Lance Jones

Human Drug Use PSY 5260

Lance Jones
GPA 3.97

Lisa Baker

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Lisa Baker
Class Notes
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This 4 page Class Notes was uploaded by Lance Jones on Wednesday September 30, 2015. The Class Notes belongs to PSY 5260 at Western Michigan University taught by Lisa Baker in Fall. Since its upload, it has received 70 views. For similar materials see /class/216925/psy-5260-western-michigan-university in Psychlogy at Western Michigan University.


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Date Created: 09/30/15
Psy 5260 Summer I 2009 Study Objectives Week Two Based on McKim Chapters 3 4 5 Julien Chapter 2 and Week Two Lecture Notes Drug Actions on the Nervous System McKim Chapter 4 Julien Chapter 2 l N E 4 V39 0 gt1 9 0 O N LA 4 UI De ne membrane potential and summarize the key factors that contribute to the resting membrane potential De ne action potential and summarize the changes in ion distribution across the membrane responsible for an action potential De ne postsynaptic potential and differentiate IPSPs and EPSPs with respect to the direction of change in the membrane potential Distinguish hormones and neurotransmitters and list some examples of each Identify the components of a neurochemical synapse Summarize the steps involved in neurochemical synaptic transmission Distinguish between ionotropic and metabotropic receptor activation Identify and brie y describe two ways that neurotransmitters may be deactivated at the synapse De ne the terms agonist and antagonist with respect to drug actions in the nervous system Identify and distinguish the two divisions of the autonomic nervous system Identify speci c drugs that in uence the functions of this system Summarize some of the key functions of the hypothalamus and relate these functions to psychoactive drug effects Identify at least two structures within the limbic system and summarize their main functions Note some reasons why these structures of importance in the study of psychoactive drugs List and give examples of the major classes of neurotransmitters List three monoamine neurotransmitters and two amino acid neurotransmitters Identify the neurochemical pathways and the key neurotransmitter most widely studied in neurobiological theories of drug dependenceaddiction 16 T01 N E 4 V39 0 gt1 9 0 Identify a class of neuropeptides and speci c examples of these neuropeptides that are involved in the body s natural response to stress and pain Describe at least ve different ways that drugs may alter neurochemical transmission Give speci c examples erance and Sensitization Conditioning of Drug Effects McKim Chapter 3 De ne drug tolerance Explain how you might depict evidence for tolerance by graphing dose response functions Cite some of the empirical evidence that multiple mechanisms appear to be responsible for the development of tolerance De ne cross tolerance If an organism developed tolerance to morphine to what other drugs would you expect them to exhibit tolerance Why De ne dispositional tolerance and summarize possible mechanisms responsible for this type of tolerance De ne pharmacodynamic tolerance and summarize possible mechanisms for this type of tolerance De ne behavioral tolerance Summarize some of the processes that may be involved in the development behavioral tolerance Summarize at least one example of behavioral tolerance based on respondent conditioning and discuss the role of conditioned compensatory responses in the development of tolerance Summarize the experimental methods and key ndings of Shepard Siegel s classic research on conditioned tolerance to morphine Summarize some of the clinical implications of Siegel s research on conditioned tolerance Summarize at least one example of behavioral tolerance based on operant conditioning Discuss these ndings with respect to the role of reinforcement De ne drug sensitization Summarize evidence for conditioned sensitization Identify other factors besides drugs that have been shown to produce sensitization to the activating effects of drugs Identify brain mechanisms that may be responsible for sensitization of behavioral arousal DependenceAddiction and Drug Self Administration McKim Chapter 5 1 Equot Equot 5 Equot 0 gt 9 9 H C H H H DJ List three models that have been proposed for explaining substance abuseaddiction Identify key historical developments that contributed to the establishment of the disease model of addiction Summarize some of the key strengths and problems or limitations of the disease model Summarize the physical dependence model Note some of the limitations of this model Identify key discoveries that contributed to the development of the positive reinforcement model Summarize key strengths and limitations or problems with this model Describe the animal model accepted as the gold standard for assessing abuse liability of psychoactive drugs Identify some drugs that are readily selfadministered by nonhuman species and some that are not typically selfadministered by nonhumans Note examples of drugs that have been shown to function as negative reinforcers in nonhuman species Summarize the key neural components of motivation and reinforcement mechanisms Discuss how research on the neural pathways of motivation and reinforcement has contributed to our understanding of the neurobiology of addiction Note similarities and differences that have been reported between nonhumans and humans with respect to drug selfadministration Summarize some of the methods used to assess the incentive value of drugs a Note some of the limitations of using response rate as a measure of the incentive value of drugs b Describe progressive ratio schedules and define breaking point How are these schedules used to characterize incentive value of drugs c Summarize choice procedures and how they may be used to assess incentive values of drugs Identify and discuss examples of other variables that have been examined in drug selfadministration research Summarize at least one research finding for each variable discussed H 0 H l H W De ne behavioral economics Summarize some of the research methods that have been employed to examine conditioned incentive and conditioned reinforcing effects of drugs a Summarize the place conditioning model b Summarize the use of second order schedules Summarize the Incentive Sensitization Theory proposed by Robinson and Berridge 1993 Discuss how this model has been used to explain substance abuse addiction Summarize the matching law and discuss drug useabuse from this perspective Discuss the use of behavioral economics in the investigation of environmental factors that in uence drug selfadministration Summarize some of the research ndings by Carroll 1993 using a behavioral economics approach to investigate PCP consumption in rhesus monkeys


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