Anatomy and phys lecture 17
Anatomy and phys lecture 17 PHCL2600
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This 4 page Class Notes was uploaded by Legacy Tanner on Tuesday October 6, 2015. The Class Notes belongs to PHCL2600 at University of Toledo taught by Williams,F in Fall 2015. Since its upload, it has received 29 views. For similar materials see Funct Anat and Pathophysiol I in Pharmaceutical Sciences at University of Toledo.
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Date Created: 10/06/15
Anatomy Lecture 17 Transmission at a chemical synapse pic in phone 0 Criteria de ning neurotransmitters 0 NT must be produced within a neuron 0 NT must be released when a neuron is stimulated depolarized Must be Ca2 dependent 0 NT must be inactivated after release 0 Released NT must produce physiological responses Action on a postsynaptic receptor NT responses are modulated by various drugs Neurotransmitters 0 Small molecules Synthesized and placed in vesicles in axon terminals 0 Neuropeptides Synthesized and packaged in vesicles in soma Transported in terminals Pic in phone and can be found in book Acetylcholine works on cholinergic synapses Pic in phone on what happens to neurotransmitters Removal of neurotransmitters Neurotransmitter elimination ensures that the signal does not overstimulate the postsynaptic membrane Pic in phone Steps of removal Diffusion of neurotransmitters away from synapse Enzymatic degradation 0 Synaptic cleft Acetylcholine 0 Inside cells Norepinephrine and Epinephrine Reuptake o Transporters Presynaptic neuron Neighboring neurogia o Intracellular degradation Effects of neurotransmitters Happens in the somatic nervous system and autonomic nervous system 0 The response depends upon the neurotransmitter released the receptor and the associated channel 0 Produce excitatory or inhibitory postsynaptic potential 0 Pic in phone on the effects Neurotransmitter receptors Neurotransmitter released into the synaptic cleft binds to ligandgated receptors 0 Pic in phone lonotropic receptors 0 Fast neurotransmission rapid effect GABA Gammaaminobutyric acid acetylcholine glycine and serotonin Pic in phone 2 functional domains 0 An extracellular neurotransmitter binding site 0 A membrane spanning domain that forms an ion channel Multimeric proteins 0 4 or 5 protein subunits 0 Each subunit contributes to the pore formation in the ion channel Channels for K Na Cl and Ca2 Pic in phone Acetylcholine binds to the nicotinic receptor Pic in phone Metabotropic receptors Slow neurotransmission slow response No ion channel in part of the receptor structure 0 2 different proteins They are indirectly linked to ionchannels Glutamate acetylcholine monoamines epinephrine and norepinephrine Pic in phone that looks like an apple