Anatomy and phys lecture 18
Anatomy and phys lecture 18 PHCL2600
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This 4 page Class Notes was uploaded by Legacy Tanner on Tuesday October 6, 2015. The Class Notes belongs to PHCL2600 at University of Toledo taught by Williams,F in Fall 2015. Since its upload, it has received 23 views. For similar materials see Funct Anat and Pathophysiol I in Pharmaceutical Sciences at University of Toledo.
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Date Created: 10/06/15
Anatomy Lecture 18 Metabotropic receptors 0 Monomeric protein with seven transmembrane domains G protein couple receptors 0 Extracellular domain has the neurotransmitter binding site 0 Intracellular domain binds to a G protein three subun s 0 Pic in phone 0 Mechanism of action Direct mechanism 0 G protein directly opens or closes an ion channel Indirect mechanism 0 G protein indirectly opens or closes an ion channel Aka interacts with something else that ends up effecting the ion channel Pic in phone Direct effect of G protein on ion channels pic in phone 0 First molecule of transmitter substance binds with receptor 0 Second receptor activates G protein 0 Third alpha subunit breaks with ion channel and opens it 0 Fourth ions enter cell produce postsynaptic potential o Metabotropic acetylcholine receptor pic in phone 0 Indirect opening of ion channels First molecule of transmitter substance binds with receptor Second receptor activates G protein Third alpha subunit breaks away activates enzyme which produces second messenger Fourth ion channel open Fifth ions enter cell produce postsynaptic potential Sixth to nucleus or other parts of cell Pic in phone 0 Postsynaptic potentials Changes in membrane permeability to ions Create a membrane potential Excitatory postsynaptic potential EPSP Inhibitory postsynaptic potential IPSP Pic in phone Excitatory postsynaptic potential EPSP Slight depolarization due to increased permeability to primarily Na and to a lesser extent Ca2 EPSP increases the likelihood of producing an action potential 0 Pic in phone Inhibitory postsynaptic potential IPSP IPSP slight hyperpolarization resulting from increased permeability to Cl or K Generation of an action potential is more dif cult than usual 0 Pic in phone Postsynaptic potentials are graded Small local changes in membrane potential Dendrites and cell body of neurons The magnitude depends on stimulus of channeb Summation is the process by which graded potentials add together 0 Net result is a larger depolarizing or hyperpolarizing graded potential Pic in phone Summation at a postsynaptic neuron pics in phone Graded potentials Has a localized current that is decremental it dies out o No threshold 0 Over a short distance 0 Has a summation Amplitude or size varies from large to small o It is a depolarization or hyperpolarization Happens in the soma and dendrites Action potentials Current propagates and is not decremental it doesn t die out Has a threshold Happens over a long distance No summation Amplitude or size is the sameal or none It is a depolarization type Happens over the length of the axon Pic on graded and action potentials in phone
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