Chapter 10 Notes
Chapter 10 Notes Microbiology 210
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This 2 page Class Notes was uploaded by Jordan Gause on Wednesday October 7, 2015. The Class Notes belongs to Microbiology 210 at University of Tennessee - Knoxville taught by Elizabeth McPherson in Fall 2015. Since its upload, it has received 88 views. For similar materials see Microbiology in Biology at University of Tennessee - Knoxville.
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Date Created: 10/07/15
Chapter 10 Notes Controlling Microbial Growth in the Body Antimicrobial Drugs A The History of Antimicrobial Agents Why does bacteria want to kill other bacteria to get rid of competition for space for itself etc B Mechanisms of Antimicrobial Action key is selective toxicity an effective antimicrobial agent must be more toxic to a pathogen than to the pathogen s host want to target bacterial cell without harming host antibacterial drugs constitute largest number and diversity of antimicrobial agents WHY envelope is different ribosomes cell wall and outer membrane also different fewer antifungal antiprotozoal and anithelmintic drugs because theses organisms are eukaryotic l nature and share many common features with humans and animals WHY difficult to target eukaryotic cells because fewer differences of effective antiviral drugs is also limited WHY have to kill host cell along with virus because virus lives in host cell 1 Different Modes of Action chemotherapeutic agents cell walls good target because bacteria have them only works when cells are growing causes cell wall to not stick together like glue on newspaper balloon ex 2 Inhibition of Cell Wall Synthesis cell wall protects a cell from the effects of osmotic pressure bacteria and fungi have cell walls humans and animals lack enzymedihydrofolic acid enzyme tetra Folic acid purine and pyrimidine nucleotides DNA and RNA drugs that act against bacterial cell walls most common antibacterial agents act by preventing the cross linkage of NAM subunits common features prevent bacteria from increasing the amount of cell wall but have no effect on existing peptidoglycan layer effective only for growing cells dormant cells are unaffected drugs effective against acidfast positive organisms disrupt the formation of the arabinoglactanmycolic acid layer the number of different kinds of pathogens a drug acts against narrowspectrum may allow for 2 types of infection take antibiotic and get diarrhea goes throughout body so may target other things in body as well come from different source immune system weaker because already sick etc 2 Effectiveness ascertained by diffusion susceptibility tests minimum inhibitory concentration test and minimum bactericidal concentration test 3 Routes of Administration adequate amount of an antimicrobial agent must reach site of infection to be effective people feel better so they stop taking their requires needle must know how antimicrobial agents are distributed to infected tissues by the blood blood vessels in the brain spinal cord and eye are almost impermeable because protected D Multiple Resistance and Cross Resistance microbes organisms resistant to 3 or more antimicrobial agents resistance to one antimicrobial agent may confer resistance to similar drugs 1 Retarding Resistance slow down take all medication for the correct medicine oral amount etc
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