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by: Sadie O'Kon

Pharmacotherapeutics NUR 3145

Sadie O'Kon
GPA 3.69

Deborah Raines

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About this Document

Deborah Raines
Class Notes
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This 2 page Class Notes was uploaded by Sadie O'Kon on Monday October 12, 2015. The Class Notes belongs to NUR 3145 at Florida Atlantic University taught by Deborah Raines in Fall. Since its upload, it has received 36 views. For similar materials see /class/221647/nur-3145-florida-atlantic-university in Nursing and Health Sciences at Florida Atlantic University.

Popular in Nursing and Health Sciences


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Date Created: 10/12/15
Compare and contrast the basic mechanisms and outcomes of delayed versus immediate hypersensitivity reactions In discussing delayed hypersensitivity integrate general concepts about cellmediated immunity Antiviral agents for CMV Cytomegalovirus CMV is a herpesvirus that is more prevalent than you might think quotBetween 50 and 85 of Americans age 40 and older harbor the virus It is a dormant virus that is generally harmless for healthy people but can be life threatening for people who are immunocompromised or undergoing cancer therapy Five antiviral agents are used to prevent CMV infections of the lungs eyes and GI tract l Iquot S P Uquot Gancyclovir used onlyfor immunocompromised patients for treatment of CMV retinitis CMV pneumonitis CMV colitis CMV antigenemia or viremia and for prevention of CMV infection in transplant recipients Major adverse effects are L r I andtlu r o 1 Valgancyclovir a pro drug version of gancyclovir used for CMV infections but has greater oral bioavailability Adverse effects same as gancyclovir including blood dyscrasias Cidofovir a nephrotoxic antiviral med onlyfor CMV retinitis in patients with AIDS who have failed on gancyclovir or foscarnet Foscarnet effective against all known herpesviruses But this medication is also nephrotoxic IV only and expensive with multiple adverse effects including electrolyte and mineral imbalances fever nausea diarrhea vomiting fatigue tremor irritability genital ulceration abnormal liver function neutropenia seizures Fomivirsen unusual because it is injected directly into the vitreous humor of the eye to treat CMV retinitis in HIV infected patients who do not respond to other drugs Note Fomivirsen is the first of a new class called quotantisensequot agents It has a single strand of DNA designed to bind to specific molecules of messenger RNA blocking synthesis of disease causing proteins Summarized from pages 1074 1076 of Lehne 2010 Reference Lehne R A 2010 Pharmacologyfor nursing care 7 ed St Louis Saunders


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