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by: Jordane Kemmer
Jordane Kemmer
GPA 3.79

Spencer Muse

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About this Document

Spencer Muse
Class Notes
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This 1 page Class Notes was uploaded by Jordane Kemmer on Thursday October 15, 2015. The Class Notes belongs to ST 590A at North Carolina State University taught by Spencer Muse in Fall. Since its upload, it has received 12 views. For similar materials see /class/223944/st-590a-north-carolina-state-university in Statistics at North Carolina State University.

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Date Created: 10/15/15
Reading Study Guide for Exam 1 0 Chapter 0 Genetics and Statistics background material 0 Chapter 12 No need to spend time studying these other than knowing the biological data types used in genomics 0 Chapter 3 Pairwise sequence alignment pages 66116 also know permutationbootstrap approaches for evaluating alignments 0 Chapter 6 Database searches scoring matrices 236238 BLAST 248258 pro lesPSIBLAST 261270 0 Chapter 4 Statistics of Sequence Alignments 122147 0 Chapter 5 Multiple Sequence Alignment 164185 210215 Some sample questions from previous exams 1 To nd out where the introns in a proteincoding DNA sequence are located we would look where in the GenBank le a The LOCUS eld b The FEATURES list c The location of introns is not provided in GenBank les 2 One of the primary reasons for using likelihood methods is a They are usually computationally quite simple b They are generally applicable even in complex situations c They are usually more accurate than Bayesian methods ctggtat taggt ccgatgtgggacttgggc 3 What is an af ne gap score Give a speci c example of an af ne gap score and illustrate its calculation using the above alignment Why might we want to use an af ne gap score 5


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