Lecture 10 Notes - Metabolic Design
Lecture 10 Notes - Metabolic Design BIL 255
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This 1 page Class Notes was uploaded by Elizabeth Mompoint on Sunday October 18, 2015. The Class Notes belongs to BIL 255 at University of Miami taught by Dr. Mallery in Fall 2015. Since its upload, it has received 11 views. For similar materials see Cellular & Molecular Biology in Biology at University of Miami.
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Date Created: 10/18/15
Cell and Molecular Biology Lecture 10 Design of Metabolism Glyceraidehyde B pihosphate MAD P r r quot glyceraldiehydezip Cells obey laws of chemlstry amp phys1cs and are capable of transforrmng MADquot w j dehydmgmage energy 13abisphosphoglycerate Energy in cells is housed in a molecule s chemical bonds ADP Cells possess chemical potential energy Cellular energy also occurs in forms such as phosphuglycerate hinase 3p hosp Tug che rate 0 Chemical concentration gradients across membranes can diffuse from phosphagwwcerate higher to lower 2 phosphogly1el 0 Electrical gradients potential differences across membranes a emlase separation of charge as much as 200000 volts per cmquot2 ospmem39wmwm Cellular transformations of energy make up metabolism amp the pathways ENERGY IN gt CELL STRUCTURE gt ENERGY OUT Pyrwate What we need to be able to do is Measure Energy in systems esp energy39s ability to do work Willard Gibbs 18391903 applied the principles of Thermodynamics to chemical systems to determine the energy content amp changes within a chemical reaction He derived the free energy equations 0 AG AH T AS AG quotDELTA Gquot O Changes in free energy occurring in a reaction are denoted by O 1n 1 AG where Mindicates a difference Thus for the reaction AB ICD I AG actual free energy at any time in a reaction I AGO39 stande free energy change under standard AG free energy C DJ minus free energyr A 3 AG measures the amount of disorder caused by a reaction the change in order inside the cell plus the change in order of the o C K 1 1 surroundingscausedbytl leiheatreleased AG is useful because it measures how liar awa from amp 7 390 equilibrium a reaction is Thus the reaction y I R gas constant 1987 X 103 Kcmol m m a O c has a Iar e ne Iative AG because cells ikee the reaction a lion I T C way l runfil equ ihr ium lb continually malarialg fresh ATP 9 However if the cell dies then most of its ATP will be hydrolyzed I 1n natural log for conveI Slon to log 10 multlply Em eqruti rlilbriutrn is reached at eqlui liifrium tggfogwerd and ac war reac Ions ovccura equa ra es an 2 3 Pameli III Essential Cell llinlogy 1il1 ed zarland Etienne 2011 I At equilibrium AG 0 and p r Keq Equilibrium Constant AG is a numerical measure of how far a reaction is from equilibrium AG is measure amount energy in system able to do work to stay away from equilibrium 0 Disorder increases thus entropy increases when useful energy that which could be used to do work is dissipated as heat 00 0 Most cells are isothermal function with a very narrow temp range 4 o to 45 o thus AH 0 O Exergonic reaction one that releases free energy 0 Endergonic reaction requires input of energy for A I B Coupled reactions often involve the linking of the hydrolysis of ATP a favored reaction to a thermos dynamically unfavored reaction therefore creating some biological order greater molecular structure