Nutrition BIBC 120
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This 3 page Class Notes was uploaded by Davon Tromp on Thursday October 22, 2015. The Class Notes belongs to BIBC 120 at University of California - San Diego taught by Staff in Fall. Since its upload, it has received 50 views. For similar materials see /class/226773/bibc-120-university-of-california-san-diego in Biochemistry and Molecular Biology at University of California - San Diego.
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Date Created: 10/22/15
Toxic effects and metabolism of alcohol in humans lmPalved aclwaxiun whzauon and dslox lmn We gums Elh nul Increaszd gt Emmy nalone lt Maldlgesllun A degradauon l Malabsuvplmn Mum 539 l l Toxic and Metabolic Disorders Caused by Ethanol Abu mm Dependencequot Emam39 Cquota 2 quot Qvgunulle lmmumlogm Dysmww Summanw fame1y mum mmumuan warms meme E umsmus ALTERATIONS Hypm Damage i mm Enevgy FEW UVquot MIC Ir AW H a Hyplemnemra ypupm ememra cwocuncu P450 mnucno u 02 74W 7 quot1me HYMWM l 2 quot nmnnemms Hypoglummmdalmr oH39 c Hypenacxamuema 55 mmquot MEUSltgtAceulaehvdl NADH Hypemncemla mm pammamn lcnlcm lncveaiad Collagen Achvauon m hapaluloxm A J Synmesvs m WW 5 quotswim Emdmg 0 mmquot mme mums lt Mmmbuw xmpavrmem mama enemm and mamu swellmgl ATP Degvanauan v ma Peroxmauan m lmpaued L valysls Amman Pyndoxme demener gt Ircveam 2 hydmxymlmn Bennsome Em 121mm u5 3 gquot quot95 5 x mm L FAEP A FA aslevmralmn Silmulahun al lmmunulogm new HyvqulycemrEV a C Ersgggggf mlcg fam2 Vlmpalrmenl m Mlluchnndnal Electron Tiansuqu Guam 5 rehno s energy waslaqa u m longrterm or by the N v MEOS Wllh the nductlon of cytochrome P135023 and otherrmcrosomal enzymes as Well FA denotesfattyaclds M e A Ethanol Drug Interactions Involving the Alcohol Dehydrogenase Pathway and Liver Microsoam Blo O Alcnhnl nan amgmvasa Almhnt aunyimgmmso Mcmhnluns Liver Acemlrieixvna Blood Almhi ii d lil ilmucn a Mm l hmmanuse Annularm la Anemirianma lUlFlnholnelt Physiologic and toxic roles of CYP2E1 the main cytochrome P450 of the microsomal ethanoloxidizing system OH Products Detoxification Glucose i Activation to toxins carcinogens 03 OH and other tree radicals Ketones 02 Fatty Acids Xenobiotics including ethanol Many endogenous and xenobioti compounds are substrates for CYPZEI and induce its activity through v mechanisms resulting in an anay o bene cial as well as harmful effects c 5 incquot mun Ann M union 2n swan c an39ous Lipid peroxidation and other consequences of alcoholic liver disease LIPID METABOLITES PEROXIDATION ETHANOL FREE Ql RADICALS ADH MICHOSOMES hAMlNOiniBUTYRIC ACID GSH a KETOBUTYRIC ACID ACETALDEHYDE METHIONINE Jv quot l u SERINE r7 gtCYSTATHIONINE SADENOSYL METHIONNE gtHOMOCYSTEINE b PHOSPHATIDYLCHOLINE AD PHOSPHATIDYLETHANOLAMINE CYSTEINE c s Lula 2DDDAnn aw Nnmmnzn 395mm 900 Hepatic vitamin A levels in subjects With normal livers chronic persistent hepatitis and various stages 0 g 700 g alcoholic injury 3 500 X z g 400 x Z 2 g 300 gt z 5 j 200 x I l QWI4ILle Naml Persistent Folly Alcohol CWYIDSlS Lmer Hepmihs my Hemlills a Amwsy my mums c s Lula 2DDDAnn aw Nnmmnzn 395mm
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