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by: Chase Heffron

week8.pdf EXSC 223 001

Chase Heffron
Anatomy and Physiology 1

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Only 1 day of lecture on here- sliding filament theory and cross bridge cycling related to muscles
Anatomy and Physiology 1
Class Notes
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This 2 page Class Notes was uploaded by Chase Heffron on Tuesday October 27, 2015. The Class Notes belongs to EXSC 223 001 at University of South Carolina taught by Thompson in Summer 2015. Since its upload, it has received 22 views. For similar materials see Anatomy and Physiology 1 in Physical Education at University of South Carolina.

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Date Created: 10/27/15
Exam questions Endomysium The sarcolemma is a phospholipid bilayer a cell membrane It has all the integral proteins associated with it etc etc the endomysium is a layer of connective tissue that surrounds each and every sarcolemma It is a ne network of collagen that forms a sheet around the sarcolemma Fascicle a fascicle is a layer of connective tissue that bundles a bunch of myo bers together lntramembranous ossi cation speci c to at bones Gets its name because it starts with no cartilage template Osteoblasts proliferate and produce osteoid Lays down and mineralizes collagen It continues to do this and eventually it gets a blood supply Then remodeling turns this into spongey bone Eventually compact bone develops around the spongey bone Don39t need to know about bone repair I band isotropic light can pass through No thick laments A band anisotropic light cannot pass through Primary function of t tubule is to transmit the signal to sr to release calcium If the sr does not join to the t tubule that function cannot take place The triad refers to the cistern of an sr the t tubule and the cistern of a different sr When hair cell goes dormant your hair falls out In normal circumstances a vellus hair will form Dormancy and active growth cycles very throughout the body Tropomysosin when muscle is relaxed it covers up the binding site on the actin Regeneration phase in tissue repair new cells are replaced in the epithelium Fibrosis Endochondral ossi cation there is a template A bony collar is produced around diaphysis This triggers the chondrocytes to die off When these die off osteoblasts replace the cartilage with bone Eventually a blood supply will penetrate the shaft with osteoblasts and osteoclasts The diaphysis forms rst Independent of this ossi cation centers form around the epiphyses Cartilage dies off and bone is produced The bone is remodeled so there is a layer of spongey bone and compact bone A satellite cell provides a source of new nuclei to skeletal muscle Satellite cells are thought to reproduce Under rare disease conditions do you lose your satellite cells Mesenchymal cells derive from the mesoderm These cells mean they are going to become a connective tissue of some kind broblasts chondroblasts osteoblasts hematopoietic stem cells In the hair bulb you have a papilla this is where a collection of blood vessel are found that bring nutrients for keratinocytes and melanocytes to nourish cells Matrix cells Titin is thought to play a role in preventing excessive stretch on a sarcomere Runs from 2 disc to m line EXAM 3 material The slidino lament theorv stf describes whats taking place when a muscle shortens Talking speci cally about the events in a sarcomere According the the STF the thin laments slide over the thick laments In a fully contracted sarcomere there is no I band The sliding lament theory suggest it is the thin laments that slide How does this work Cross bridge cycling A cross bridge refers to a myosin globular head binding to an actin molecule Cycling refers to the forming and breaking of cross bridges You can relate the number of cross bridges formed to the amount of force produced by muscle Myosin is in the cocked position when it forms the bond When an inorganic phosphate Pi falls off the myosin head the myosin uncocks and pulls the thin lament to the sarcomere Then ADP is released Next ATP binds to the myosin head this weakens the bond between myosin and actin This causes the myosin to separate The myosin then breaks down ATP into ADP and Pi and recocks


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