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by: Bailey Metcalf
Bailey Metcalf

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About this Document

Exercise Physiology
Joseph White
Class Notes
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Popular in Exercise Physiology

Popular in Physical Education

This 2 page Class Notes was uploaded by Bailey Metcalf on Sunday March 27, 2016. The Class Notes belongs to 3805 at East Carolina University taught by Joseph White in Winter 2016. Since its upload, it has received 22 views. For similar materials see Exercise Physiology in Physical Education at East Carolina University.


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Date Created: 03/27/16
Exercise and Neuroprotection 1. 13% of Americans take anti-depressant medications 2. Effects of Physical Activity on Brain Health a. Chronic physical activity improves brain health b. Regular exercise has a beneficial impact on i. Depression ii. Quality of sleep iii. Cognitive function in older adults 3. Hippocampus a. Part of the limbic system b. Responsible for processing long term memory and emotional responses c. One of the first areas to suffer damage in Alzheimer’s disease 4. Exercise and Hippocampal Adaptations a. Exercise has been demonstrated to promoted hippocampal plasticity form a variety of aspects, including neurogenesis- making new nerve cells, dendritic complexity and synaptic plasticity. b. Voluntary running decreases depression-like behaviors and improves hippocampus-dependent spatial learning and memory through restoring hippocampal neurogenesis and increasing dendritic plasticity. 5. Exercise and Neurotropic factors a. The capacity of exercise to induce the production of neurotropic factors that nourish and protect neurons in the CNS is putatively regarded as the principal mechanism mediating its anitdepressive action 6. Exercise and Brain derived Neurotropic Growth Factor a. In animal models, BDNF is induced in various regions of the brain with exercise, most robustly in the hippocampus b. BDNF promotes many aspects of brain development, including neuronal cell survival, differentiation, migration 7. Blood Brain Barrier a. Certain molecules cant cross the BBB so that’s the way of protection 8. Adiponectin a. Hormone released into the blood stream after synthesis by mature adipocytes that possesses anti-diabetic, anti- inflammatory, anti-atherogenic and cardio-protective properties b. Adiponectin may be a new member of the neurotropic family c. Physical exercise stimulated hippocampal neurogenesis and anti-depressive activity are absent in mice after knocking out the gene for Adiponectin synthesis 9. Exercise and the Runner’s high: all about endorphins.. right? a. A runner’s high is described as an ephemeral pleasant phenomenon that may be experienced during long term running b. Running increases plasma levels of beta endorphin an opioid and anadamide in mice and men c. However unlike the lipophilic anadamide, beta endorphin cant cross the bbb rendering central effects of peripheral opioid unlikely 10. Exercise, Cannabinoids and receptors a. In mice the reduction in anxiety like behavior after acute long distance running depends on cannabinoid-1 CB1 receptors on forebrain b. Pain reduction in contrast depends on peripheral CBI and 2 receptors


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