New User Special Price Expires in

Let's log you in.

Sign in with Facebook


Don't have a StudySoup account? Create one here!


Create a StudySoup account

Be part of our community, it's free to join!

Sign up with Facebook


Create your account
By creating an account you agree to StudySoup's terms and conditions and privacy policy

Already have a StudySoup account? Login here

BioChem Week 6

by: Lauran Notetaker

BioChem Week 6 CHEM 3653 - 001

Lauran Notetaker

Preview These Notes for FREE

Get a free preview of these Notes, just enter your email below.

Unlock Preview
Unlock Preview

Preview these materials now for free

Why put in your email? Get access to more of this material and other relevant free materials for your school

View Preview

About this Document

Week 6
Dr. Paul A. Sims
Class Notes
25 ?




Popular in Biochemistry

Popular in Chemistry

This 4 page Class Notes was uploaded by Lauran Notetaker on Tuesday March 29, 2016. The Class Notes belongs to CHEM 3653 - 001 at University of Oklahoma taught by Dr. Paul A. Sims in Winter 2016. Since its upload, it has received 9 views. For similar materials see Biochemistry in Chemistry at University of Oklahoma.


Reviews for BioChem Week 6


Report this Material


What is Karma?


Karma is the currency of StudySoup.

You can buy or earn more Karma at anytime and redeem it for class notes, study guides, flashcards, and more!

Date Created: 03/29/16
February 23, 2016 Chapter 6: The Three-Dimensional Structure of Proteins Levels of Protein Structure Primary (sequence of amino acid residues) Secondary Tertiary Quaternary - Protein with one or more structural units 1.45A 1.33 1.25A -1.25 0.08 = 40% 0.2 0.08 0.2 Ramachandran Plot Phi and Psi bond angles be concerned with Alpha helices and Beta strands Discoverers of the Alpha Helix Linus Pauling Robert Corey C-terminal g- N-terminal g+ The Alpha Helix right handed 3.6 residues 5.4A pitch intramolecular C=O and N-H 4 residues ahead in helix side chains splayed out Beta strands and sheets sheets are more than one strand Antiparallel C N C N C N C N 2 residues span 7.0A polyproline II helix is left-handed Fibrous Protein Structure silk keratin - hair, fingernails The intermediate filament protein Alpha keratin Two right handed alpha helices intertwine to form a left-handed super coil Collagen abundant in connective tissue if you don't hydroxylize proline coil it wont be as tight NMR - Nuclear Magnetic Resonance Globular Proteins, typically fold into defined structures Triphosphate Isomerase (TIM) February 25, 2016 Homework 7 moved to Next Thursday Hydrophobic side chains inside of protein are non polar Polar (charged) face toward surface of protein “zinc fingers” cysteines and histidines Christian Anfinsen and Bovine Ribonuclease A - RNase can still act as an enzyme unfolded? No need to keep shape (folded) found that most of the info specifying the tertiary structure is carried in the amino acid sequence Protein Folding Thermodynamics Proteins vary in the extent to which the folded state is favored by enthalpic or entropic factors Disulfide bonds greatly increase stability Levinthal’s Paradox and Dawkins Typing Monkey once you type a key, you keep it Chaperones promote proper folding of proteins and thereby prevent the formation of aggregated states associated with disease -Ex. Alzheimers Dangers of misfolding Alzheimers disease Parkinson’s disease Type II Diabetes Cataracts Can we predict secondary structure from amino acid sequence? Empirical methods are ~ 80% accurate Chapter 7: Protein Function and Evolution “Derivation of Protein-Ligand Binding Equations” Keq = [PL] = k2 [P][L] k1 (Where the k1,k2, and k3 come from are on the handout mentioned above) He is not going to ask detailed questions about the biology of antibodies antigen binding sites antigen bonds to antibody and interactions are mediated by shape and charge Gobins (Mb) myoglobin is monomeric, releases O2 in tissues (Hb) Hemoglobin is tetrameric, transports O2 from lungs to peripheral tissues Heme is an Irom Porphyrin Mb or Hb without heme is called apoprotein with heme is holoprotein O2 binds at the heme Fe2+ oxygen binding curve for myoglobin Y= [L] Kd+[L]


Buy Material

Are you sure you want to buy this material for

25 Karma

Buy Material

BOOM! Enjoy Your Free Notes!

We've added these Notes to your profile, click here to view them now.


You're already Subscribed!

Looks like you've already subscribed to StudySoup, you won't need to purchase another subscription to get this material. To access this material simply click 'View Full Document'

Why people love StudySoup

Bentley McCaw University of Florida

"I was shooting for a perfect 4.0 GPA this semester. Having StudySoup as a study aid was critical to helping me achieve my goal...and I nailed it!"

Amaris Trozzo George Washington University

"I made $350 in just two days after posting my first study guide."

Bentley McCaw University of Florida

"I was shooting for a perfect 4.0 GPA this semester. Having StudySoup as a study aid was critical to helping me achieve my goal...and I nailed it!"


"Their 'Elite Notetakers' are making over $1,200/month in sales by creating high quality content that helps their classmates in a time of need."

Become an Elite Notetaker and start selling your notes online!

Refund Policy


All subscriptions to StudySoup are paid in full at the time of subscribing. To change your credit card information or to cancel your subscription, go to "Edit Settings". All credit card information will be available there. If you should decide to cancel your subscription, it will continue to be valid until the next payment period, as all payments for the current period were made in advance. For special circumstances, please email


StudySoup has more than 1 million course-specific study resources to help students study smarter. If you’re having trouble finding what you’re looking for, our customer support team can help you find what you need! Feel free to contact them here:

Recurring Subscriptions: If you have canceled your recurring subscription on the day of renewal and have not downloaded any documents, you may request a refund by submitting an email to

Satisfaction Guarantee: If you’re not satisfied with your subscription, you can contact us for further help. Contact must be made within 3 business days of your subscription purchase and your refund request will be subject for review.

Please Note: Refunds can never be provided more than 30 days after the initial purchase date regardless of your activity on the site.