New User Special Price Expires in

Let's log you in.

Sign in with Facebook


Don't have a StudySoup account? Create one here!


Create a StudySoup account

Be part of our community, it's free to join!

Sign up with Facebook


Create your account
By creating an account you agree to StudySoup's terms and conditions and privacy policy

Already have a StudySoup account? Login here

Genetics Week 7

by: Lauran Notetaker

Genetics Week 7 BIOL/PBIO 3333

Lauran Notetaker

Preview These Notes for FREE

Get a free preview of these Notes, just enter your email below.

Unlock Preview
Unlock Preview

Preview these materials now for free

Why put in your email? Get access to more of this material and other relevant free materials for your school

View Preview

About this Document

Week 7
Dr. Jim Thompson
Class Notes
25 ?




Popular in Genetics

Popular in Biology

This 3 page Class Notes was uploaded by Lauran Notetaker on Tuesday March 29, 2016. The Class Notes belongs to BIOL/PBIO 3333 at University of Oklahoma taught by Dr. Jim Thompson in Winter 2016. Since its upload, it has received 14 views. For similar materials see Genetics in Biology at University of Oklahoma.


Reviews for Genetics Week 7


Report this Material


What is Karma?


Karma is the currency of StudySoup.

You can buy or earn more Karma at anytime and redeem it for class notes, study guides, flashcards, and more!

Date Created: 03/29/16
February 29, 2016 V. DNA Structure and Replication B. Nucleotides C. DNA Replication 1. Semi-conservative 2. DNA Replication Fork 3. Okazaki fragments 4. Error Correction VI. Mutation A. Types 1. Somatic vs germinal 2. Point Mutation B. Methods of Detection C. Rate D. Some causes E. Complementation Exam 2 will have bonus from Exam 1 DNA Replication 1. Complex process helix error detection and correction processes at work 2. Extremely accurate in prokaryotes 1000 nucleotides/sec error rate = 1 error/10^9-10^10 bp slower in eukaryotes perhaps due to involvement of DNA with histone proteins (structural part of the chromosome) For replication 1. template (a model) strand of DNA 2. Primer (a short starting sequence, since DNA polymerase can only add a new nucleotide to a pre-existing 3’ OH position) 3. dNTPs (deoxynucleotide triphosphates) dATP, dCTP, dTTP, dGTP *remember templates are antiparallel Key DNA Replication Enzymes (Prokaryote Model) 1. helicase - causes unwinding of the double helix 2. topoisomerase (e.g gyrase) - relaxes DNA super coil during DNA replications 3. Single-strand binding proteins 4. DNA polymerase III (=pol III) 5. Primase (as part of the primosome) 6. DNA polymerase I (=pol I) -remove RNA primer -error correction function 7. Ligase March 2, 2016 V. DNA Structure and Replication B. Nucleotides C. DNA Replication 1. Semi-conservative 2. DNA Replication Fork 3. Okazaki fragments 4. Error Correction VI. Mutation A. Types 1. Somatic vs germinal 2. Point Mutation B. Methods of Detection C. Rate D. Some causes E. Complementation Participation #3 of 8 germinal vs somatic mutation (body cells) mosaicism - cancer point mutation = common example Genetic damage Mutation Rate: the probability with which a particular mutational event takes place per biological entity per reproductive cycle [DNA Repair] Mutation Event transversion - less common; more likely to alter amino acid Mutation Rate Estimates (for spontaneous mutations) 20-43 new nucleotide changes per gamete per cell generation in humans 7 x 10^-11 mutations/bp/replication Some of the molecular classes of point mutations add or delete one or more nucleotides “frameshift” mutations (we will explore these in more detail later) base (nucleotide) substitution for example: replace A - T with a G - C Hydrolysis of a purine base, A or G occurs 1000 times an hour in every cell. Deamination removes -NH2 group. Can change C to U Thymine dimers - big cause of skin cancer Nick - break in sugar phosphate backbone ligase seals the repair strand prochiral - not chiral itself krebs cycle think in terms of free energy enzymes lower height of activation barrier making the reaction go faster March 4, 2016 Exam 2


Buy Material

Are you sure you want to buy this material for

25 Karma

Buy Material

BOOM! Enjoy Your Free Notes!

We've added these Notes to your profile, click here to view them now.


You're already Subscribed!

Looks like you've already subscribed to StudySoup, you won't need to purchase another subscription to get this material. To access this material simply click 'View Full Document'

Why people love StudySoup

Bentley McCaw University of Florida

"I was shooting for a perfect 4.0 GPA this semester. Having StudySoup as a study aid was critical to helping me achieve my goal...and I nailed it!"

Allison Fischer University of Alabama

"I signed up to be an Elite Notetaker with 2 of my sorority sisters this semester. We just posted our notes weekly and were each making over $600 per month. I LOVE StudySoup!"

Steve Martinelli UC Los Angeles

"There's no way I would have passed my Organic Chemistry class this semester without the notes and study guides I got from StudySoup."

Parker Thompson 500 Startups

"It's a great way for students to improve their educational experience and it seemed like a product that everybody wants, so all the people participating are winning."

Become an Elite Notetaker and start selling your notes online!

Refund Policy


All subscriptions to StudySoup are paid in full at the time of subscribing. To change your credit card information or to cancel your subscription, go to "Edit Settings". All credit card information will be available there. If you should decide to cancel your subscription, it will continue to be valid until the next payment period, as all payments for the current period were made in advance. For special circumstances, please email


StudySoup has more than 1 million course-specific study resources to help students study smarter. If you’re having trouble finding what you’re looking for, our customer support team can help you find what you need! Feel free to contact them here:

Recurring Subscriptions: If you have canceled your recurring subscription on the day of renewal and have not downloaded any documents, you may request a refund by submitting an email to

Satisfaction Guarantee: If you’re not satisfied with your subscription, you can contact us for further help. Contact must be made within 3 business days of your subscription purchase and your refund request will be subject for review.

Please Note: Refunds can never be provided more than 30 days after the initial purchase date regardless of your activity on the site.