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BioChem Week 8

by: Lauran Notetaker

BioChem Week 8 CHEM 3653 - 001

Lauran Notetaker

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About this Document

Week 8
Dr. Paul A. Sims
Class Notes
25 ?




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This 3 page Class Notes was uploaded by Lauran Notetaker on Wednesday March 30, 2016. The Class Notes belongs to CHEM 3653 - 001 at University of Oklahoma taught by Dr. Paul A. Sims in Winter 2016. Since its upload, it has received 10 views. For similar materials see Biochemistry in Chemistry at University of Oklahoma.


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Date Created: 03/30/16
March 8, 2016 know chymotrypsin mechanism LBHB - low barrier hydrogen bond covalent catalysis occurs when a group on the enzyme temporarily becomes covalently bonded Protein groups that can act as covalent catalysts Se, Tyr, —OH, —O- CO2 H+ Acetoacetate Enolate Acetone enzymes need “helper” molecules called coenzyme Nearly 1/3 of all known enzymes require metal ions for activity Fe(II), Fe(III), Cu(II), Mn(II), Co(II) are usually catalytic Na+, K+, Ca+ are usually structural Mg2+, Zn2+ can be either catalytic or structural Serine Proteases tertiary structure is more conserved than primary W. W. Cleland Pre-steady state [ES] forming (us-ms) steady state: [ES] almost constant (s-min) Michaelis Constant (Km) indicates the substrate concentration at which the reaction rate 1/2 Vmax Enzyme activity will be high when [S] is above Km 10^8, 10^9 diffusion control March 10, 2016 Exam II March 24 Km = k2 + k3 k1 order of release is random, random bi-bi (Cleland Nomenclature) Reversible inhibitors (noncovalently bound) uncompetitive - lines are parallel mixed or noncompetitive if alpha = alpha’ (very rare case) then it is called “pure competitive” and lines intersect on x-axis of the double reciprocal plot Irreversible Inhibition (covalent modification) Regulation of Enzyme Activity Substrate Level Control -Rx rate up with up [S] - in general a large change in [S] would be required to effect a significant change in enzyme activity (thus this is a crude meaning of regulation) Regulation at committed steps of pathways covalent modification Chapter 9 glyceraldehyde - an aldose dihydroxyacetone (a ketose)


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